Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1453987..1454509 Replicon chromosome
Accession NZ_CP090508
Organism Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)


Gene name parE Uniprot ID A0A060HA53
Locus tag LZ758_RS06790 Protein ID WP_038229230.1
Coordinates 1453987..1454274 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060HDF9
Locus tag LZ758_RS06795 Protein ID WP_004085758.1
Coordinates 1454267..1454509 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ758_RS06760 (LZ758_06760) 1449198..1449884 + 687 WP_038229254.1 TIGR02453 family protein -
LZ758_RS06765 (LZ758_06765) 1450016..1451014 + 999 WP_004085391.1 MBL fold metallo-hydrolase -
LZ758_RS06770 (LZ758_06770) 1450980..1452174 + 1195 Protein_1332 DUF5710 domain-containing protein -
LZ758_RS06775 (LZ758_06775) 1452298..1452723 + 426 WP_038229235.1 antirestriction protein -
LZ758_RS06780 (LZ758_06780) 1452991..1453248 + 258 WP_038229233.1 hypothetical protein -
LZ758_RS06785 (LZ758_06785) 1453333..1453899 - 567 WP_038229232.1 recombinase family protein -
LZ758_RS06790 (LZ758_06790) 1453987..1454274 - 288 WP_038229230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ758_RS06795 (LZ758_06795) 1454267..1454509 - 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LZ758_RS06800 (LZ758_06800) 1454761..1455066 - 306 WP_004091409.1 BrnA antitoxin family protein -
LZ758_RS06805 (LZ758_06805) 1455053..1455343 - 291 WP_038229226.1 BrnT family toxin -
LZ758_RS12245 1455418..1455693 + 276 WP_004091404.1 XRE family transcriptional regulator -
LZ758_RS06815 (LZ758_06815) 1455804..1456124 + 321 WP_004091397.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ758_RS06820 (LZ758_06820) 1456254..1456580 + 327 WP_004091396.1 DNA-binding protein -
LZ758_RS06825 (LZ758_06825) 1456722..1457648 - 927 WP_051606204.1 hypothetical protein -
LZ758_RS06830 (LZ758_06830) 1458054..1458470 - 417 WP_038229223.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1451716..1473913 22197
- inside IScluster/Tn - - 1453333..1459650 6317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11163.63 Da        Isoelectric Point: 5.9570

>T230946 WP_038229230.1 NZ_CP090508:c1454274-1453987 [Xylella fastidiosa subsp. morus]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Download         Length: 288 bp

>T230946 NZ_CP125731:2706464-2706571 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8774.77 Da        Isoelectric Point: 6.9881

>AT230946 WP_004085758.1 NZ_CP090508:c1454509-1454267 [Xylella fastidiosa subsp. morus]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Download         Length: 243 bp

>AT230946 NZ_CP125731:c2706417-2706351 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HA53

Antitoxin

Source ID Structure
AlphaFold DB A0A060HDF9

References