Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 971612..972198 | Replicon | chromosome |
| Accession | NZ_CP090508 | ||
| Organism | Xylella fastidiosa subsp. morus strain Riv11 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LZ758_RS04495 | Protein ID | WP_038228269.1 |
| Coordinates | 971612..971866 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | B2I6C9 |
| Locus tag | LZ758_RS04500 | Protein ID | WP_004085025.1 |
| Coordinates | 971863..972198 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ758_RS04455 (LZ758_04455) | 966856..967062 | - | 207 | WP_233341868.1 | hypothetical protein | - |
| LZ758_RS04460 (LZ758_04460) | 967319..967924 | - | 606 | WP_040123201.1 | conjugal transfer protein TrbN | - |
| LZ758_RS04465 (LZ758_04465) | 967930..968304 | - | 375 | WP_040123200.1 | hypothetical protein | - |
| LZ758_RS04470 (LZ758_04470) | 968451..968705 | + | 255 | WP_040123199.1 | hypothetical protein | - |
| LZ758_RS04475 (LZ758_04475) | 968702..969604 | + | 903 | WP_234056418.1 | YdaU family protein | - |
| LZ758_RS04480 (LZ758_04480) | 969585..970274 | + | 690 | WP_038228265.1 | hypothetical protein | - |
| LZ758_RS04485 (LZ758_04485) | 970271..970732 | + | 462 | WP_234056374.1 | hypothetical protein | - |
| LZ758_RS04490 (LZ758_04490) | 970861..971559 | + | 699 | WP_038228267.1 | hypothetical protein | - |
| LZ758_RS04495 (LZ758_04495) | 971612..971866 | + | 255 | WP_038228269.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LZ758_RS04500 (LZ758_04500) | 971863..972198 | + | 336 | WP_004085025.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LZ758_RS04505 (LZ758_04505) | 972378..972677 | - | 300 | WP_004089519.1 | HigA family addiction module antitoxin | - |
| LZ758_RS04510 (LZ758_04510) | 972687..972968 | - | 282 | WP_011098058.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ758_RS04515 (LZ758_04515) | 973316..974030 | + | 715 | Protein_887 | site-specific DNA-methyltransferase | - |
| LZ758_RS04520 (LZ758_04520) | 974017..974481 | - | 465 | WP_011098056.1 | low molecular weight protein-tyrosine-phosphatase | - |
| LZ758_RS04525 (LZ758_04525) | 974478..975251 | - | 774 | WP_004089528.1 | 3-deoxy-manno-octulosonate cytidylyltransferase | - |
| LZ758_RS04530 (LZ758_04530) | 975686..976597 | + | 912 | WP_230577717.1 | iron-sulfur cluster carrier protein ApbC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 963627..979113 | 15486 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9679.16 Da Isoelectric Point: 11.2766
>T230944 WP_038228269.1 NZ_CP090508:971612-971866 [Xylella fastidiosa subsp. morus]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSHNTDKGAVESIRAWLKSN
GVTP
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSHNTDKGAVESIRAWLKSN
GVTP
Download Length: 255 bp
>T230944 NZ_CP125731:c2492967-2492791 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12324.07 Da Isoelectric Point: 5.6556
>AT230944 WP_004085025.1 NZ_CP090508:971863-972198 [Xylella fastidiosa subsp. morus]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT
Download Length: 336 bp
>AT230944 NZ_CP125731:c2492745-2492329 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|