Detailed information of TA system TA230942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 530734..531345
• Replicon: chromosome
• Accession: NZ_CP090508
• Organism: Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A060HHU8
• Locus tag: LZ758_RS02510
• Protein ID: WP_024749166.1
• Coordinates: 531046..531345 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q879U0
• Locus tag: LZ758_RS02505
• Protein ID: WP_004085003.1
• Coordinates: 530734..531042 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ758_RS02480 (LZ758_02480)	525857..526261	+	405	WP_230577601.1	hypothetical protein	-
LZ758_RS02485 (LZ758_02485)	526399..527757	+	1359	WP_234509106.1	DUF3383 domain-containing protein	-
LZ758_RS02490 (LZ758_02490)	527767..528204	+	438	WP_038230291.1	DUF3277 family protein	-
LZ758_RS02495 (LZ758_02495)	528201..528623	+	423	WP_004085005.1	putative phage tail assembly chaperone	-
LZ758_RS02500 (LZ758_02500)	528771..530660	+	1890	WP_038230294.1	hypothetical protein	-
LZ758_RS02505 (LZ758_02505)	530734..531042	-	309	WP_004085003.1	putative addiction module antidote protein	Antitoxin
LZ758_RS02510 (LZ758_02510)	531046..531345	-	300	WP_024749166.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ758_RS02515 (LZ758_02515)	531433..531738	+	306	WP_230577600.1	hypothetical protein	-
LZ758_RS02520 (LZ758_02520)	531882..532202	+	321	WP_234509108.1	hypothetical protein	-
LZ758_RS02525 (LZ758_02525)	532202..532519	+	318	WP_012382585.1	hypothetical protein	-
LZ758_RS02530 (LZ758_02530)	532516..533346	+	831	WP_234056377.1	hypothetical protein	-
LZ758_RS02535 (LZ758_02535)	533343..533984	+	642	WP_040123250.1	Gp138 family membrane-puncturing spike protein	-
LZ758_RS02540 (LZ758_02540)	533981..534334	+	354	WP_234056392.1	hypothetical protein	-
LZ758_RS02545 (LZ758_02545)	534345..534650	-	306	WP_038211623.1	putative addiction module antidote protein	-
LZ758_RS02550 (LZ758_02550)	534654..534950	-	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ758_RS02555 (LZ758_02555)	535049..536194	+	1146	WP_038211620.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	433970..537918	103948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-98)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11364.14 Da
• Isoelectric Point: 10.3861

>T230942 WP_024749166.1 NZ_CP090508:c531345-531046 [Xylella fastidiosa subsp. morus]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Nucleotide

• Length: 300 bp

>T230942 NZ_CP125731:2092960-2093063 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11060.61 Da
• Isoelectric Point: 4.6535

>AT230942 WP_004085003.1 NZ_CP090508:c531042-530734 [Xylella fastidiosa subsp. morus]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Nucleotide

• Length: 309 bp

>AT230942 NZ_CP125731:c2093101-2092830 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A060HHU8

Antitoxin

• AlphaFold DB: A0A060HCD4