Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 479746..480357 Replicon chromosome
Accession NZ_CP090508
Organism Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag LZ758_RS02130 Protein ID WP_024749166.1
Coordinates 480058..480357 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag LZ758_RS02125 Protein ID WP_004085003.1
Coordinates 479746..480054 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ758_RS12175 474840..474962 - 123 WP_267964463.1 hypothetical protein -
LZ758_RS02100 (LZ758_02100) 475077..475274 + 198 WP_234509097.1 hypothetical protein -
LZ758_RS12180 475275..476192 + 918 WP_267964464.1 DUF3383 family protein -
LZ758_RS12185 476159..476769 + 611 Protein_403 DUF3383 family protein -
LZ758_RS02110 (LZ758_02110) 476779..477216 + 438 WP_038230291.1 DUF3277 family protein -
LZ758_RS02115 (LZ758_02115) 477213..477635 + 423 WP_004085005.1 putative phage tail assembly chaperone -
LZ758_RS02120 (LZ758_02120) 477783..479672 + 1890 WP_038230294.1 hypothetical protein -
LZ758_RS02125 (LZ758_02125) 479746..480054 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
LZ758_RS02130 (LZ758_02130) 480058..480357 - 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ758_RS02135 (LZ758_02135) 480445..480750 + 306 WP_230577600.1 hypothetical protein -
LZ758_RS02140 (LZ758_02140) 480766..481215 + 450 WP_230577599.1 hypothetical protein -
LZ758_RS02145 (LZ758_02145) 481215..481532 + 318 WP_012382585.1 hypothetical protein -
LZ758_RS02150 (LZ758_02150) 481529..482359 + 831 WP_234056377.1 hypothetical protein -
LZ758_RS02155 (LZ758_02155) 482356..482997 + 642 WP_040123250.1 Gp138 family membrane-puncturing spike protein -
LZ758_RS02160 (LZ758_02160) 482994..483347 + 354 WP_040123277.1 hypothetical protein -
LZ758_RS02165 (LZ758_02165) 483403..483696 - 294 WP_004085592.1 putative addiction module antidote protein -
LZ758_RS02170 (LZ758_02170) 483699..483995 - 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ758_RS02175 (LZ758_02175) 484098..485243 + 1146 WP_038211620.1 baseplate J/gp47 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 433970..537918 103948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T230939 WP_024749166.1 NZ_CP090508:c480357-480058 [Xylella fastidiosa subsp. morus]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T230939 NZ_CP125731:1074064-1074399 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT230939 WP_004085003.1 NZ_CP090508:c480054-479746 [Xylella fastidiosa subsp. morus]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT230939 NZ_CP125731:1073816-1074064 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References