Detailed information of TA system TA230936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2584792..2585293
• Replicon: chromosome
• Accession: NZ_CP090506
• Organism: Xylella fastidiosa subsp. morus strain Riv19

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: Q87CA4
• Locus tag: LZ757_RS11890
• Protein ID: WP_011097988.1
• Coordinates: 2584792..2585058 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: LZ757_RS11895
• Protein ID: WP_012382644.1
• Coordinates: 2585042..2585293 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ757_RS11860 (LZ757_11860)	2581434..2582195	-	762	WP_004085598.1	Bax inhibitor-1/YccA family protein	-
LZ757_RS11885 (LZ757_11885)	2583387..2584781	+	1395	WP_040123316.1	hypothetical protein	-
LZ757_RS11890 (LZ757_11890)	2584792..2585058	-	267	WP_011097988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ757_RS11895 (LZ757_11895)	2585042..2585293	-	252	WP_012382644.1	DUF6290 family protein	Antitoxin
LZ757_RS11900 (LZ757_11900)	2585380..2585793	+	414	WP_234056426.1	hypothetical protein	-
LZ757_RS12275	2586003..2586131	+	129	WP_267959514.1	hypothetical protein	-
LZ757_RS11905 (LZ757_11905)	2586385..2586765	-	381	WP_038228433.1	DUF596 domain-containing protein	-
LZ757_RS11910 (LZ757_11910)	2586897..2587271	-	375	WP_038228431.1	hypothetical protein	-
LZ757_RS11915 (LZ757_11915)	2587268..2588638	-	1371	WP_230577640.1	DUF769 domain-containing protein	-
LZ757_RS12280	2588792..2588920	+	129	WP_267959513.1	hypothetical protein	-
LZ757_RS11920 (LZ757_11920)	2589174..2589551	-	378	WP_038228427.1	DUF596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (9-79)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10163.79 Da
• Isoelectric Point: 10.6086

>T230936 WP_011097988.1 NZ_CP090506:c2585058-2584792 [Xylella fastidiosa subsp. morus]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T230936 NZ_CP125731:721255-721551 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9460.57 Da
• Isoelectric Point: 5.1032

>AT230936 WP_012382644.1 NZ_CP090506:c2585293-2585042 [Xylella fastidiosa subsp. morus]
MHLSGGFDMATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLG
LDD

Nucleotide

• Length: 252 bp

>AT230936 NZ_CP125731:721553-721948 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: A0A060HDH1