Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1491608..1492190 Replicon chromosome
Accession NZ_CP090506
Organism Xylella fastidiosa subsp. morus strain Riv19

Toxin (Protein)


Gene name shpA Uniprot ID A0A060HA48
Locus tag LZ757_RS07085 Protein ID WP_038229226.1
Coordinates 1491900..1492190 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A060HE88
Locus tag LZ757_RS07080 Protein ID WP_004091409.1
Coordinates 1491608..1491913 (-) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ757_RS07045 (LZ757_07045) 1486863..1487861 + 999 WP_004085391.1 MBL fold metallo-hydrolase -
LZ757_RS07050 (LZ757_07050) 1487827..1489021 + 1195 Protein_1378 DUF5710 domain-containing protein -
LZ757_RS07055 (LZ757_07055) 1489145..1489570 + 426 WP_038229235.1 antirestriction protein -
LZ757_RS07060 (LZ757_07060) 1489838..1490095 + 258 WP_038229233.1 hypothetical protein -
LZ757_RS07065 (LZ757_07065) 1490180..1490746 - 567 WP_038229232.1 recombinase family protein -
LZ757_RS07070 (LZ757_07070) 1490834..1491121 - 288 WP_038229230.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ757_RS07075 (LZ757_07075) 1491114..1491356 - 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin -
LZ757_RS07080 (LZ757_07080) 1491608..1491913 - 306 WP_004091409.1 BrnA antitoxin family protein Antitoxin
LZ757_RS07085 (LZ757_07085) 1491900..1492190 - 291 WP_038229226.1 BrnT family toxin Toxin
LZ757_RS07090 (LZ757_07090) 1492412..1492540 + 129 WP_234492591.1 helix-turn-helix domain-containing protein -
LZ757_RS07095 (LZ757_07095) 1492651..1492971 + 321 WP_004091397.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ757_RS07100 (LZ757_07100) 1493101..1493427 + 327 WP_004091396.1 DNA-binding protein -
LZ757_RS07105 (LZ757_07105) 1493569..1494495 - 927 WP_051606204.1 hypothetical protein -
LZ757_RS07110 (LZ757_07110) 1494901..1495317 - 417 WP_038229223.1 IS200/IS605 family transposase -
LZ757_RS07115 (LZ757_07115) 1495340..1496497 + 1158 WP_038229247.1 RNA-guided endonuclease TnpB family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1488563..1510763 22200
- inside IScluster/Tn - - 1490180..1496497 6317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11304.62 Da        Isoelectric Point: 6.0917

>T230931 WP_038229226.1 NZ_CP090506:c1492190-1491900 [Xylella fastidiosa subsp. morus]
VERYFEWDDKKAESNFRKHGIRFDEAALAFDDPFAVSEQNRIENGEQRWQTIGMAGGCLLLLVAHTVHFEDDGIEVVRII
SARRVDRKERRRYEHG

Download         Length: 291 bp

>T230931 NZ_CP125718:919724-920086 [Staphylococcus casei]
ATGATGAGAAGAGGCGACGTTTATTTAGCTGATTTATCACCAGTGCAAGGGTCTGAACAAGGGGGAATTAGACCTGTCGT
GATTATACAAAACGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCAGCAATTACTGGTAGGATAAATAAAGCTA
AGATACCAACACATGTAGAAATAGAAAAAAGTAAGTATAAGTTAGATAAAGATTCTGTTATTTTGTTAGAACAAATTAGA
ACTTTAGATAAAAACAGACTGAAAGAAAAATTAACTTATCTCTCTGAAGATAAAATGAGAGAAGTAAACAATGCTATCGA
CATAAGCTTAGGATTACATAGTGTTAGGACAAATAAATCCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11684.43 Da        Isoelectric Point: 9.4870

>AT230931 WP_004091409.1 NZ_CP090506:c1491913-1491608 [Xylella fastidiosa subsp. morus]
MNMVRYKQSELPPLTEERKAELKALAKKPDSEIDYSDIPPLDESFWARAVPNPFFKPVKTHASVRIDSDVLAWLKSQGKG
YQTRMNAILREAMLRSLHQQE

Download         Length: 306 bp

>AT230931 NZ_CP125718:919557-919727 [Staphylococcus casei]
ATGGTAAGTTTTACTCAAAGCAGAAATCACAGTATTGAACAATTACTAAAGGAAGGCTATTCTCAAATGGCCGACTTAAA
CCTCTCCCTTGCAGCAGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAACGAAGTCTACATCAGCTCTAAGAATA
ACAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A060HA48


Antitoxin

Source ID Structure
AlphaFold DB A0A060HE88

References