Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 1490834..1491356 | Replicon | chromosome |
| Accession | NZ_CP090506 | ||
| Organism | Xylella fastidiosa subsp. morus strain Riv19 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A060HA53 |
| Locus tag | LZ757_RS07070 | Protein ID | WP_038229230.1 |
| Coordinates | 1490834..1491121 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A060HDF9 |
| Locus tag | LZ757_RS07075 | Protein ID | WP_004085758.1 |
| Coordinates | 1491114..1491356 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ757_RS07040 (LZ757_07040) | 1486045..1486731 | + | 687 | WP_038229254.1 | TIGR02453 family protein | - |
| LZ757_RS07045 (LZ757_07045) | 1486863..1487861 | + | 999 | WP_004085391.1 | MBL fold metallo-hydrolase | - |
| LZ757_RS07050 (LZ757_07050) | 1487827..1489021 | + | 1195 | Protein_1378 | DUF5710 domain-containing protein | - |
| LZ757_RS07055 (LZ757_07055) | 1489145..1489570 | + | 426 | WP_038229235.1 | antirestriction protein | - |
| LZ757_RS07060 (LZ757_07060) | 1489838..1490095 | + | 258 | WP_038229233.1 | hypothetical protein | - |
| LZ757_RS07065 (LZ757_07065) | 1490180..1490746 | - | 567 | WP_038229232.1 | recombinase family protein | - |
| LZ757_RS07070 (LZ757_07070) | 1490834..1491121 | - | 288 | WP_038229230.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ757_RS07075 (LZ757_07075) | 1491114..1491356 | - | 243 | WP_004085758.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LZ757_RS07080 (LZ757_07080) | 1491608..1491913 | - | 306 | WP_004091409.1 | BrnA antitoxin family protein | - |
| LZ757_RS07085 (LZ757_07085) | 1491900..1492190 | - | 291 | WP_038229226.1 | BrnT family toxin | - |
| LZ757_RS07090 (LZ757_07090) | 1492412..1492540 | + | 129 | WP_234492591.1 | helix-turn-helix domain-containing protein | - |
| LZ757_RS07095 (LZ757_07095) | 1492651..1492971 | + | 321 | WP_004091397.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ757_RS07100 (LZ757_07100) | 1493101..1493427 | + | 327 | WP_004091396.1 | DNA-binding protein | - |
| LZ757_RS07105 (LZ757_07105) | 1493569..1494495 | - | 927 | WP_051606204.1 | hypothetical protein | - |
| LZ757_RS07110 (LZ757_07110) | 1494901..1495317 | - | 417 | WP_038229223.1 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1488563..1510763 | 22200 | |
| - | inside | IScluster/Tn | - | - | 1490180..1496497 | 6317 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11163.63 Da Isoelectric Point: 5.9570
>T230930 WP_038229230.1 NZ_CP090506:c1491121-1490834 [Xylella fastidiosa subsp. morus]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL
Download Length: 288 bp
>T230930 NZ_CP125718:908392-908595 [Staphylococcus casei]
ATGAAATCTAAAGTCATTTATGTATCAGGTATAAATAACAAGGCACAACAAAAGCAACTTGAAGAACATTTGAAATTGAT
AGATGGTGTGAAGAAAGTATCAGTAAATCAAACTAATGAGACCATATCAATTGATTTTGAGACGCCAGCAAGTTTAAATA
ACCTAGAAAAAGAAGTGTATGATTTAGGCTTTACCATCCTATAA
ATGAAATCTAAAGTCATTTATGTATCAGGTATAAATAACAAGGCACAACAAAAGCAACTTGAAGAACATTTGAAATTGAT
AGATGGTGTGAAGAAAGTATCAGTAAATCAAACTAATGAGACCATATCAATTGATTTTGAGACGCCAGCAAGTTTAAATA
ACCTAGAAAAAGAAGTGTATGATTTAGGCTTTACCATCCTATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8774.77 Da Isoelectric Point: 6.9881
>AT230930 WP_004085758.1 NZ_CP090506:c1491356-1491114 [Xylella fastidiosa subsp. morus]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG
Download Length: 243 bp
>AT230930 NZ_CP125718:908083-908376 [Staphylococcus casei]
ATGGAGGAAATACAAAAAGCACACCACTCGGAACAGAATAAAGCTAATTTAAAATCGAGATTGAATCGTATAGAGGGTCA
AGTTAGAGCAATTAATCGAATGATCGATGAAGATGTATATTGTGATGATGTGTTGACACAAATTAGAGCTACACGTTCAG
CATTAAATAGTGTGGCAACAAAGTTATTAGATCACCATATGAAAAGCTGTATCATGAATAAAGTCAATCAAGGACAACAA
GAAGAAGCGATGGAAGAATTATTAGTTACTTTTCAAAAATTAATGAAAGATTAG
ATGGAGGAAATACAAAAAGCACACCACTCGGAACAGAATAAAGCTAATTTAAAATCGAGATTGAATCGTATAGAGGGTCA
AGTTAGAGCAATTAATCGAATGATCGATGAAGATGTATATTGTGATGATGTGTTGACACAAATTAGAGCTACACGTTCAG
CATTAAATAGTGTGGCAACAAAGTTATTAGATCACCATATGAAAAGCTGTATCATGAATAAAGTCAATCAAGGACAACAA
GAAGAAGCGATGGAAGAATTATTAGTTACTTTTCAAAAATTAATGAAAGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HA53 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HDF9 |