Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 1154441..1155129 Replicon chromosome
Accession NZ_CP090506
Organism Xylella fastidiosa subsp. morus strain Riv19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ757_RS05395 Protein ID WP_038230656.1
Coordinates 1154441..1154845 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ757_RS05400 Protein ID WP_230577702.1
Coordinates 1154842..1155129 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ757_RS05345 (LZ757_05345) 1149581..1150154 + 574 Protein_1043 IS607 family transposase -
LZ757_RS05350 (LZ757_05350) 1150148..1150309 + 162 WP_014607806.1 helix-turn-helix domain-containing protein -
LZ757_RS05355 (LZ757_05355) 1150474..1151217 + 744 WP_230577707.1 transposase -
LZ757_RS05360 (LZ757_05360) 1151121..1151354 + 234 WP_230577706.1 transposase -
LZ757_RS05365 (LZ757_05365) 1151371..1151604 + 234 WP_038230061.1 DUF3383 family protein -
LZ757_RS05370 (LZ757_05370) 1151614..1152051 + 438 WP_234056347.1 DUF3277 family protein -
LZ757_RS05375 (LZ757_05375) 1152048..1152470 + 423 WP_234056346.1 putative phage tail assembly chaperone -
LZ757_RS05380 (LZ757_05380) 1152497..1152661 + 165 WP_196242993.1 hypothetical protein -
LZ757_RS05385 (LZ757_05385) 1152720..1153706 + 987 WP_234056345.1 phage tail tape measure protein -
LZ757_RS05390 (LZ757_05390) 1153703..1154422 + 720 WP_230577703.1 hypothetical protein -
LZ757_RS05395 (LZ757_05395) 1154441..1154845 - 405 WP_038230656.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ757_RS05400 (LZ757_05400) 1154842..1155129 - 288 WP_230577702.1 antitoxin Antitoxin
LZ757_RS05405 (LZ757_05405) 1155274..1156044 + 771 WP_040123188.1 hypothetical protein -
LZ757_RS05410 (LZ757_05410) 1156044..1156361 + 318 WP_012382585.1 hypothetical protein -
LZ757_RS05415 (LZ757_05415) 1156358..1157188 + 831 WP_038230303.1 hypothetical protein -
LZ757_RS05420 (LZ757_05420) 1157185..1157826 + 642 WP_012382583.1 Gp138 family membrane-puncturing spike protein -
LZ757_RS05425 (LZ757_05425) 1157823..1158176 + 354 WP_040123185.1 hypothetical protein -
LZ757_RS05430 (LZ757_05430) 1158314..1158553 + 240 WP_011097871.1 antitoxin -
LZ757_RS05435 (LZ757_05435) 1158562..1158870 + 309 WP_004089386.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1143426..1161898 18472


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(21-59)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14667.97 Da        Isoelectric Point: 5.6955

>T230929 WP_038230656.1 NZ_CP090506:c1154845-1154441 [Xylella fastidiosa subsp. morus]
VSGYMLDTNIISDIIRNPFGAVACRIEHVGYPNICTSVIVAAELRYGCTKNGSVKLLSRVQDILKTLPLLPLEIPVDTTY
GSIRAELEAAGQLIGANDLLIAAHAYVLGLTLVTDNTREFSRIRGLDVQNWLER

Download         Length: 405 bp

>T230929 NZ_CP125718:c109324-109055 [Staphylococcus casei]
ATGGCTAAACTGAATATTACCTTTTCACCACAAGCTTTTGATGATTATGAATATTTTCAAACTAAAGATAGAAAAATGGT
TAAAAGAATAAATCAATTATTAAAAAGCATCTCTAGAGATGGCGCATTAGACGGTATCGGGAAACCCGAAAAGTTAGTTG
GCAATTTTTCGGGATATTACAGTAGACGAATCAACCAAGAACATAGATTAGTATATACAGTAAATGACAATGCCATATTA
GTTGCCTCTTGCAGATATCATTACAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11006.61 Da        Isoelectric Point: 4.5716

>AT230929 WP_230577702.1 NZ_CP090506:c1155129-1154842 [Xylella fastidiosa subsp. morus]
MDAVPMPISSPLSRTKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPITRPTNIVELLHEWRRETPLDPEDQ
FPDIDDMPVQPEDIL

Download         Length: 288 bp

>AT230929 NZ_CP125718:c109573-109325 [Staphylococcus casei]
ATGATTGTTAAATCTTATACTTATGTCCGTAAACACTTTAAAGATATGATTAATAAAGTGAATGACGATAGTGATGCGAT
AACAATTACAACAAAAGATCGTAATGCAGTTATAATGTCAGAAGATAATTATAATGAAATAATGGAAACACTATACTTAC
AACAAAACCCTGCCAACGCGAAGCATTTATCAGAATCTATTGAAGACCTCGAGCGCGGCAATGTAAAAACTAAGGATATT
TTAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References