Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumAB/COG3657-dnstrm_HI1420 |
| Location | 533534..534126 | Replicon | chromosome |
| Accession | NZ_CP090506 | ||
| Organism | Xylella fastidiosa subsp. morus strain Riv19 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | A0A060HCK8 |
| Locus tag | LZ757_RS02545 | Protein ID | WP_004085590.1 |
| Coordinates | 533830..534126 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | PumB | Uniprot ID | - |
| Locus tag | LZ757_RS02540 | Protein ID | WP_004085592.1 |
| Coordinates | 533534..533827 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ757_RS02500 (LZ757_02500) | 529877..530185 | - | 309 | WP_004085003.1 | putative addiction module antidote protein | - |
| LZ757_RS02505 (LZ757_02505) | 530189..530488 | - | 300 | WP_024749166.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ757_RS02510 (LZ757_02510) | 530576..530881 | + | 306 | WP_230577600.1 | hypothetical protein | - |
| LZ757_RS02515 (LZ757_02515) | 530897..531346 | + | 450 | WP_230577599.1 | hypothetical protein | - |
| LZ757_RS02520 (LZ757_02520) | 531346..531663 | + | 318 | WP_012382585.1 | hypothetical protein | - |
| LZ757_RS02525 (LZ757_02525) | 531660..532490 | + | 831 | WP_234056377.1 | hypothetical protein | - |
| LZ757_RS02530 (LZ757_02530) | 532487..533128 | + | 642 | WP_040123250.1 | Gp138 family membrane-puncturing spike protein | - |
| LZ757_RS02535 (LZ757_02535) | 533125..533478 | + | 354 | WP_040123277.1 | hypothetical protein | - |
| LZ757_RS02540 (LZ757_02540) | 533534..533827 | - | 294 | WP_004085592.1 | putative addiction module antidote protein | Antitoxin |
| LZ757_RS02545 (LZ757_02545) | 533830..534126 | - | 297 | WP_004085590.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ757_RS02550 (LZ757_02550) | 534229..534987 | + | 759 | WP_234492567.1 | baseplate J/gp47 family protein | - |
| LZ757_RS02555 (LZ757_02555) | 535017..535373 | + | 357 | WP_228762937.1 | hypothetical protein | - |
| LZ757_RS02560 (LZ757_02560) | 535370..535930 | + | 561 | WP_038230308.1 | DUF2612 domain-containing protein | - |
| LZ757_RS02565 (LZ757_02565) | 535934..537097 | + | 1164 | WP_234056379.1 | tail fiber protein | - |
| LZ757_RS02570 (LZ757_02570) | 537394..537546 | + | 153 | WP_162531331.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 437682..539227 | 101545 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11169.70 Da Isoelectric Point: 10.0610
>T230927 WP_004085590.1 NZ_CP090506:c534126-533830 [Xylella fastidiosa subsp. morus]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE
Download Length: 297 bp
>T230927 NZ_CP125717:490252-490602 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10246.59 Da Isoelectric Point: 5.6232
>AT230927 WP_004085592.1 NZ_CP090506:c533827-533534 [Xylella fastidiosa subsp. morus]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH
Download Length: 294 bp
>AT230927 NZ_CP125717:489965-490246 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|