Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 529877..530488 Replicon chromosome
Accession NZ_CP090506
Organism Xylella fastidiosa subsp. morus strain Riv19

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag LZ757_RS02505 Protein ID WP_024749166.1
Coordinates 530189..530488 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag LZ757_RS02500 Protein ID WP_004085003.1
Coordinates 529877..530185 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ757_RS02475 (LZ757_02475) 525014..525403 + 390 WP_234492563.1 hypothetical protein -
LZ757_RS02480 (LZ757_02480) 525404..526900 + 1497 WP_038230289.1 DUF3383 domain-containing protein -
LZ757_RS02485 (LZ757_02485) 526910..527347 + 438 WP_038230291.1 DUF3277 family protein -
LZ757_RS02490 (LZ757_02490) 527344..527766 + 423 WP_011097875.1 putative phage tail assembly chaperone -
LZ757_RS02495 (LZ757_02495) 527914..529803 + 1890 WP_038230294.1 hypothetical protein -
LZ757_RS02500 (LZ757_02500) 529877..530185 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
LZ757_RS02505 (LZ757_02505) 530189..530488 - 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ757_RS02510 (LZ757_02510) 530576..530881 + 306 WP_230577600.1 hypothetical protein -
LZ757_RS02515 (LZ757_02515) 530897..531346 + 450 WP_230577599.1 hypothetical protein -
LZ757_RS02520 (LZ757_02520) 531346..531663 + 318 WP_012382585.1 hypothetical protein -
LZ757_RS02525 (LZ757_02525) 531660..532490 + 831 WP_234056377.1 hypothetical protein -
LZ757_RS02530 (LZ757_02530) 532487..533128 + 642 WP_040123250.1 Gp138 family membrane-puncturing spike protein -
LZ757_RS02535 (LZ757_02535) 533125..533478 + 354 WP_040123277.1 hypothetical protein -
LZ757_RS02540 (LZ757_02540) 533534..533827 - 294 WP_004085592.1 putative addiction module antidote protein -
LZ757_RS02545 (LZ757_02545) 533830..534126 - 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ757_RS02550 (LZ757_02550) 534229..534987 + 759 WP_234492567.1 baseplate J/gp47 family protein -
LZ757_RS02555 (LZ757_02555) 535017..535373 + 357 WP_228762937.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 437682..539227 101545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T230926 WP_024749166.1 NZ_CP090506:c530488-530189 [Xylella fastidiosa subsp. morus]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T230926 NZ_CP125672:542277-542618 [Leptospira kirschneri]
ATGATTCGTGGTGAGATCTGGTGGGTAGACTTAGGAATTCCATTCGGAAGTGAACCTGGGTTTAAGCGTCCAGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAATATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAACGTTTTGATCGGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATTGTG
ACTTTAGATAAGGAAAGGTTTATTGAACGAGTGGGAAAGCTTAAATCAAGTAAGATCAATGAAGTTGAAGTAGGTCTCAA
ATTAGTTACAGGTTTAGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT230926 WP_004085003.1 NZ_CP090506:c530185-529877 [Xylella fastidiosa subsp. morus]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT230926 NZ_CP125672:542042-542290 [Leptospira kirschneri]
ATGAAAACTGCAATTTCGATTCCAGATGAATTATTCAAGACTGCTGAGAAAACGGCAAAAAAACTTGGAATACCTCGAAG
CCAACTCTTTGCAAAAGCATTAGAAGAATTTATTCAATCCCATAGTAAAGAATCTGTAACAGAGAAATTAAATAAAATTT
ATAACAGAAAATCCAAAGAACTTAAAAGTAATATCACAGATTTATCTGTAGAGTTATTGCGCAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References