Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 478925..479536 Replicon chromosome
Accession NZ_CP090506
Organism Xylella fastidiosa subsp. morus strain Riv19

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag LZ757_RS02120 Protein ID WP_024749166.1
Coordinates 479237..479536 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag LZ757_RS02115 Protein ID WP_004085003.1
Coordinates 478925..479233 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ757_RS02090 (LZ757_02090) 474062..474451 + 390 WP_234492563.1 hypothetical protein -
LZ757_RS02095 (LZ757_02095) 474452..475948 + 1497 WP_038230289.1 DUF3383 domain-containing protein -
LZ757_RS02100 (LZ757_02100) 475958..476395 + 438 WP_038230291.1 DUF3277 family protein -
LZ757_RS02105 (LZ757_02105) 476392..476814 + 423 WP_011097875.1 putative phage tail assembly chaperone -
LZ757_RS02110 (LZ757_02110) 476962..478851 + 1890 WP_038230294.1 hypothetical protein -
LZ757_RS02115 (LZ757_02115) 478925..479233 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
LZ757_RS02120 (LZ757_02120) 479237..479536 - 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ757_RS02125 (LZ757_02125) 479624..479929 + 306 WP_230577600.1 hypothetical protein -
LZ757_RS02130 (LZ757_02130) 479945..480394 + 450 WP_230577599.1 hypothetical protein -
LZ757_RS02135 (LZ757_02135) 480394..480711 + 318 WP_012382585.1 hypothetical protein -
LZ757_RS02140 (LZ757_02140) 480708..481538 + 831 WP_234056377.1 hypothetical protein -
LZ757_RS02145 (LZ757_02145) 481535..482176 + 642 WP_040123250.1 Gp138 family membrane-puncturing spike protein -
LZ757_RS02150 (LZ757_02150) 482173..482526 + 354 WP_234056392.1 hypothetical protein -
LZ757_RS02155 (LZ757_02155) 482537..482842 - 306 WP_038211623.1 putative addiction module antidote protein -
LZ757_RS02160 (LZ757_02160) 482846..483142 - 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ757_RS02165 (LZ757_02165) 483241..483999 + 759 WP_234492564.1 baseplate J/gp47 family protein -
LZ757_RS02170 (LZ757_02170) 484029..484385 + 357 WP_228762937.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 437682..539227 101545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T230923 WP_024749166.1 NZ_CP090506:c479536-479237 [Xylella fastidiosa subsp. morus]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T230923 NZ_CP125669:2763152-2763547 [Acinetobacter sp. KCTC 92772]
ATGTCCACGGCTAATCGTGTTTTTGAGTTGCAAGCCAGTCGCTTTATGATTGTTTTGCAACTGTTAATTTTTATTTTCCT
GATGATTTTACTCTATCAGCTATTAGCTTTGGGGATTTGGCTGCTGTGTCTGGGGATCATGGTCATTGCCTGGTTCAGGT
TTTTGCAGCAACCTCAAGTCAAGCGTTTTGAACATCTGGAAGATCAAGACTGGTCATTTGAGTTTGCCGTTTCAGATCTG
CCGATACAGCGTCGGCAAATTGTGAAAATGATCGACCACCACTGCTATGTTGTCCTCTATTTTTCTGCTTCTCATGACAA
AACCTGCATCATTTGGTGGGATCAATTGCCCGTTACACAGTGGAAAAACCTAAAAACACTGGTAAAACTATGCTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT230923 WP_004085003.1 NZ_CP090506:c479233-478925 [Xylella fastidiosa subsp. morus]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT230923 NZ_CP125669:2762908-2763165 [Acinetobacter sp. KCTC 92772]
ATGTCCGATGAAATGACACTTGAAGAACGTAAGGTGATTTATCGTTCACGTCGTGGTTTAAAAGAAATTGATGTGTATTT
TGATCCCTACGTCAAAAACTATTATCTCAGTGCAGACCCAGCAGAAAAGGCCTTGTTTGCCGAACTGGTTGATCAGGAAG
ACCCTGACTTGCTGGACTGGTTTATGGAAGTGGGTGAAGCGCCAAGAGCTGAAATCAAGGAATTTATCCTAAAATTAAAA
CAGTATGTCCACGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References