230920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2584964..2585465 Replicon chromosome
Accession NZ_CP090504
Organism Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag LZ755_RS11925 Protein ID WP_011097988.1
Coordinates 2584964..2585230 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag LZ755_RS11930 Protein ID WP_012382644.1
Coordinates 2585214..2585465 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ755_RS11895 (LZ755_11895) 2581606..2582367 - 762 WP_004085598.1 Bax inhibitor-1/YccA family protein -
LZ755_RS11920 (LZ755_11920) 2583559..2584953 + 1395 WP_040123316.1 hypothetical protein -
LZ755_RS11925 (LZ755_11925) 2584964..2585230 - 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ755_RS11930 (LZ755_11930) 2585214..2585465 - 252 WP_012382644.1 DUF6290 family protein Antitoxin
LZ755_RS11935 (LZ755_11935) 2585552..2585965 + 414 WP_234056426.1 hypothetical protein -
LZ755_RS12320 2586175..2586303 + 129 WP_267959514.1 hypothetical protein -
LZ755_RS11940 (LZ755_11940) 2586557..2586937 - 381 WP_038228433.1 DUF596 domain-containing protein -
LZ755_RS11945 (LZ755_11945) 2587069..2587443 - 375 WP_038228431.1 hypothetical protein -
LZ755_RS11950 (LZ755_11950) 2587440..2588810 - 1371 WP_230577640.1 DUF769 domain-containing protein -
LZ755_RS12325 2588964..2589092 + 129 WP_267959513.1 hypothetical protein -
LZ755_RS11955 (LZ755_11955) 2589346..2589723 - 378 WP_038228427.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(9-79)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T230920 WP_011097988.1 NZ_CP090504:c2585230-2584964 [Xylella fastidiosa subsp. morus]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T230920 NZ_CP125660:2677845-2678024 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9460.57 Da        Isoelectric Point: 5.1032

>AT230920 WP_012382644.1 NZ_CP090504:c2585465-2585214 [Xylella fastidiosa subsp. morus]
MHLSGGFDMATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLG
LDD

Download         Length: 252 bp

>AT230920 NZ_CP125660:c2678170-2677948 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure

References