Detailed information of TA system TA230919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 2115569..2116100
• Replicon: chromosome
• Accession: NZ_CP090504
• Organism: Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A060HEY7
• Locus tag: LZ755_RS09995
• Protein ID: WP_038230161.1
• Coordinates: 2115569..2115850 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A060H9I0
• Locus tag: LZ755_RS10000
• Protein ID: WP_004086967.1
• Coordinates: 2115837..2116100 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ755_RS09955 (LZ755_09955)	2110809..2111441	+	633	WP_040123076.1	phage portal protein	-
LZ755_RS09960 (LZ755_09960)	2111438..2112442	+	1005	WP_234509070.1	HK97 family phage prohead protease	-
LZ755_RS09965 (LZ755_09965)	2112511..2113311	+	801	WP_234509132.1	phage major capsid protein	-
LZ755_RS09970 (LZ755_09970)	2113329..2113589	+	261	WP_027700442.1	hypothetical protein	-
LZ755_RS09975 (LZ755_09975)	2113589..2113912	+	324	WP_027700441.1	hypothetical protein	-
LZ755_RS09980 (LZ755_09980)	2113909..2114430	+	522	WP_038230165.1	hypothetical protein	-
LZ755_RS09985 (LZ755_09985)	2114406..2114948	+	543	WP_038230164.1	hypothetical protein	-
LZ755_RS09990 (LZ755_09990)	2114945..2115532	+	588	WP_027700438.1	phage baseplate assembly protein V	-
LZ755_RS09995 (LZ755_09995)	2115569..2115850	-	282	WP_038230161.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LZ755_RS10000 (LZ755_10000)	2115837..2116100	-	264	WP_004086967.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LZ755_RS10005 (LZ755_10005)	2116264..2116587	+	324	WP_228304176.1	GPW/gp25 family protein	-
LZ755_RS10010 (LZ755_10010)	2116587..2117480	+	894	WP_038230566.1	baseplate J/gp47 family protein	-
LZ755_RS10015 (LZ755_10015)	2117473..2118030	+	558	WP_040123338.1	phage tail protein I	-
LZ755_RS10020 (LZ755_10020)	2118038..2119009	+	972	WP_234056270.1	phage tail protein	-
LZ755_RS10025 (LZ755_10025)	2118939..2119616	+	678	WP_234056269.1	contractile injection system protein, VgrG/Pvc8 family	-
LZ755_RS10030 (LZ755_10030)	2120032..2121051	-	1020	WP_038230156.1	tetraacyldisaccharide 4'-kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2104416..2127450	23034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10834.28 Da
• Isoelectric Point: 7.5505

>T230919 WP_038230161.1 NZ_CP090504:c2115850-2115569 [Xylella fastidiosa subsp. morus]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVVEALACDHPLEPRHHDHALTGGWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T230919 NZ_CP125660:2273205-2273321 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9525.98 Da
• Isoelectric Point: 5.6033

>AT230919 WP_004086967.1 NZ_CP090504:c2116100-2115837 [Xylella fastidiosa subsp. morus]
MSANAVVRARVDTHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT230919 NZ_CP125660:c2273495-2273316 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A060HEY7

Antitoxin

• AlphaFold DB: A0A060H9I0