Detailed information of TA system TA230917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsR-graA/MqsR-HigA
• Location: 1772709..1773374
• Replicon: chromosome
• Accession: NZ_CP090504
• Organism: Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A060HKF7
• Locus tag: LZ755_RS08455
• Protein ID: WP_038230541.1
• Coordinates: 1773072..1773374 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LZ755_RS08450
• Protein ID: WP_004085172.1
• Coordinates: 1772709..1772984 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ755_RS08425 (LZ755_08425)	1768838..1770430	-	1593	WP_040123119.1	tail fiber domain-containing protein	-
LZ755_RS08430 (LZ755_08430)	1770438..1770995	-	558	WP_027700436.1	phage tail protein I	-
LZ755_RS08435 (LZ755_08435)	1770988..1771881	-	894	WP_234056296.1	baseplate J/gp47 family protein	-
LZ755_RS08440 (LZ755_08440)	1771881..1772204	-	324	WP_228304176.1	GPW/gp25 family protein	-
LZ755_RS08445 (LZ755_08445)	1772417..1772698	+	282	WP_004085174.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ755_RS08450 (LZ755_08450)	1772709..1772984	+	276	WP_004085172.1	HigA family addiction module antitoxin	Antitoxin
LZ755_RS08455 (LZ755_08455)	1773072..1773374	+	303	WP_038230541.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LZ755_RS08460 (LZ755_08460)	1773377..1773778	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	-
LZ755_RS08465 (LZ755_08465)	1773847..1774434	-	588	WP_040123117.1	phage baseplate assembly protein V	-
LZ755_RS08470 (LZ755_08470)	1774431..1774973	-	543	WP_038230164.1	hypothetical protein	-
LZ755_RS08475 (LZ755_08475)	1774949..1775470	-	522	WP_038230165.1	hypothetical protein	-
LZ755_RS12285	1775467..1775595	-	129	WP_267964582.1	hypothetical protein	-
LZ755_RS08480 (LZ755_08480)	1775570..1775791	-	222	WP_234553082.1	hypothetical protein	-
LZ755_RS08485 (LZ755_08485)	1775791..1776051	-	261	WP_027700442.1	hypothetical protein	-
LZ755_RS08490 (LZ755_08490)	1776069..1777943	-	1875	WP_038230171.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1752280..1802985	50705

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10972.77 Da
• Isoelectric Point: 8.0251

>T230917 WP_038230541.1 NZ_CP090504:1773072-1773374 [Xylella fastidiosa subsp. morus]
MEKGTPHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCAVVLALTSADFYKSMTTYTDHTLFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T230917 NZ_CP125660:c2219571-2219395 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10072.68 Da
• Isoelectric Point: 10.2184

>AT230917 WP_004085172.1 NZ_CP090504:1772709-1772984 [Xylella fastidiosa subsp. morus]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Nucleotide

• Length: 276 bp

>AT230917 NZ_CP125660:2219354-2219454 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Structures

Toxin

• AlphaFold DB: A0A060HKF7