Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1491016..1491538 Replicon chromosome
Accession NZ_CP090504
Organism Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)


Gene name parE Uniprot ID A0A060HA53
Locus tag LZ755_RS07085 Protein ID WP_038229230.1
Coordinates 1491016..1491303 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060HDF9
Locus tag LZ755_RS07090 Protein ID WP_004085758.1
Coordinates 1491296..1491538 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ755_RS07055 (LZ755_07055) 1486227..1486913 + 687 WP_038229254.1 TIGR02453 family protein -
LZ755_RS07060 (LZ755_07060) 1487045..1488043 + 999 WP_004085391.1 MBL fold metallo-hydrolase -
LZ755_RS07065 (LZ755_07065) 1488009..1489203 + 1195 Protein_1380 DUF5710 domain-containing protein -
LZ755_RS07070 (LZ755_07070) 1489327..1489752 + 426 WP_038229235.1 antirestriction protein -
LZ755_RS07075 (LZ755_07075) 1490020..1490277 + 258 WP_038229233.1 hypothetical protein -
LZ755_RS07080 (LZ755_07080) 1490362..1490928 - 567 WP_038229232.1 recombinase family protein -
LZ755_RS07085 (LZ755_07085) 1491016..1491303 - 288 WP_038229230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ755_RS07090 (LZ755_07090) 1491296..1491538 - 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LZ755_RS07095 (LZ755_07095) 1491790..1492095 - 306 WP_004091409.1 BrnA antitoxin family protein -
LZ755_RS07100 (LZ755_07100) 1492082..1492372 - 291 WP_038229226.1 BrnT family toxin -
LZ755_RS12265 1492447..1492722 + 276 WP_004091404.1 XRE family transcriptional regulator -
LZ755_RS07110 (LZ755_07110) 1492833..1493153 + 321 WP_004091397.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ755_RS07115 (LZ755_07115) 1493283..1493609 + 327 WP_004091396.1 DNA-binding protein -
LZ755_RS07120 (LZ755_07120) 1493751..1494677 - 927 WP_051606204.1 hypothetical protein -
LZ755_RS07125 (LZ755_07125) 1495083..1495499 - 417 WP_038229223.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1488745..1510945 22200
- inside IScluster/Tn - - 1490362..1496679 6317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11163.63 Da        Isoelectric Point: 5.9570

>T230914 WP_038229230.1 NZ_CP090504:c1491303-1491016 [Xylella fastidiosa subsp. morus]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Download         Length: 288 bp

>T230914 NZ_CP125660:c1348966-1348220 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8774.77 Da        Isoelectric Point: 6.9881

>AT230914 WP_004085758.1 NZ_CP090504:c1491538-1491296 [Xylella fastidiosa subsp. morus]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Download         Length: 243 bp

>AT230914 NZ_CP125660:c1348220-1348050 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HA53

Antitoxin

Source ID Structure
AlphaFold DB A0A060HDF9

References