Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 1154609..1155282 Replicon chromosome
Accession NZ_CP090504
Organism Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ755_RS05385 Protein ID WP_038230656.1
Coordinates 1154609..1155013 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ755_RS05390 Protein ID WP_038230657.1
Coordinates 1155010..1155282 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ755_RS05335 (LZ755_05335) 1149749..1150322 + 574 Protein_1040 IS607 family transposase -
LZ755_RS05340 (LZ755_05340) 1150316..1150477 + 162 WP_014607806.1 helix-turn-helix domain-containing protein -
LZ755_RS05345 (LZ755_05345) 1150642..1151385 + 744 WP_230577707.1 transposase -
LZ755_RS05350 (LZ755_05350) 1151289..1151522 + 234 WP_230577706.1 transposase -
LZ755_RS05355 (LZ755_05355) 1151539..1151772 + 234 WP_038230061.1 DUF3383 family protein -
LZ755_RS05360 (LZ755_05360) 1151782..1152219 + 438 WP_234056347.1 DUF3277 family protein -
LZ755_RS05365 (LZ755_05365) 1152216..1152638 + 423 WP_234056346.1 putative phage tail assembly chaperone -
LZ755_RS05370 (LZ755_05370) 1152665..1152829 + 165 WP_196242993.1 hypothetical protein -
LZ755_RS05375 (LZ755_05375) 1152888..1153874 + 987 WP_234056345.1 phage tail tape measure protein -
LZ755_RS05380 (LZ755_05380) 1153871..1154590 + 720 WP_230577703.1 hypothetical protein -
LZ755_RS05385 (LZ755_05385) 1154609..1155013 - 405 WP_038230656.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ755_RS05390 (LZ755_05390) 1155010..1155282 - 273 WP_038230657.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LZ755_RS05395 (LZ755_05395) 1155442..1156212 + 771 WP_040123188.1 hypothetical protein -
LZ755_RS05400 (LZ755_05400) 1156212..1156529 + 318 WP_012382585.1 hypothetical protein -
LZ755_RS05405 (LZ755_05405) 1156526..1157356 + 831 WP_038230303.1 hypothetical protein -
LZ755_RS05410 (LZ755_05410) 1157353..1157994 + 642 WP_012382583.1 Gp138 family membrane-puncturing spike protein -
LZ755_RS05415 (LZ755_05415) 1157991..1158344 + 354 WP_040123185.1 hypothetical protein -
LZ755_RS05420 (LZ755_05420) 1158482..1158721 + 240 WP_011097871.1 antitoxin -
LZ755_RS05425 (LZ755_05425) 1158730..1159038 + 309 WP_004089386.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ755_RS05430 (LZ755_05430) 1159188..1159946 + 759 WP_234492564.1 baseplate J/gp47 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1143594..1162065 18471


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14667.97 Da        Isoelectric Point: 5.6955

>T230913 WP_038230656.1 NZ_CP090504:c1155013-1154609 [Xylella fastidiosa subsp. morus]
VSGYMLDTNIISDIIRNPFGAVACRIEHVGYPNICTSVIVAAELRYGCTKNGSVKLLSRVQDILKTLPLLPLEIPVDTTY
GSIRAELEAAGQLIGANDLLIAAHAYVLGLTLVTDNTREFSRIRGLDVQNWLER

Download         Length: 405 bp

>T230913 NZ_CP125660:518544-518894 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10493.00 Da        Isoelectric Point: 4.7010

>AT230913 WP_038230657.1 NZ_CP090504:c1155282-1155010 [Xylella fastidiosa subsp. morus]
MPISSPLSRTKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPITRPTNIVELLHEWRRETPLDPEDQFPDID
DMPVQPEDIL

Download         Length: 273 bp

>AT230913 NZ_CP125660:518258-518539 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References