Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 529907..530518 Replicon chromosome
Accession NZ_CP090504
Organism Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag LZ755_RS02510 Protein ID WP_024749166.1
Coordinates 530219..530518 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag LZ755_RS02505 Protein ID WP_004085003.1
Coordinates 529907..530215 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ755_RS02475 (LZ755_02475) 525029..525433 + 405 WP_230577601.1 hypothetical protein -
LZ755_RS02480 (LZ755_02480) 525434..526930 + 1497 WP_038230289.1 DUF3383 domain-containing protein -
LZ755_RS02485 (LZ755_02485) 526940..527377 + 438 WP_038230291.1 DUF3277 family protein -
LZ755_RS02490 (LZ755_02490) 527374..527796 + 423 WP_011097875.1 putative phage tail assembly chaperone -
LZ755_RS02495 (LZ755_02495) 527823..527987 + 165 WP_014607750.1 hypothetical protein -
LZ755_RS02500 (LZ755_02500) 527944..529833 + 1890 WP_038230294.1 hypothetical protein -
LZ755_RS02505 (LZ755_02505) 529907..530215 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
LZ755_RS02510 (LZ755_02510) 530219..530518 - 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ755_RS02515 (LZ755_02515) 530606..530911 + 306 WP_230577600.1 hypothetical protein -
LZ755_RS02520 (LZ755_02520) 530927..531376 + 450 WP_230577599.1 hypothetical protein -
LZ755_RS02525 (LZ755_02525) 531376..531693 + 318 WP_012382585.1 hypothetical protein -
LZ755_RS02530 (LZ755_02530) 531690..532520 + 831 WP_234056377.1 hypothetical protein -
LZ755_RS02535 (LZ755_02535) 532517..533158 + 642 WP_040123250.1 Gp138 family membrane-puncturing spike protein -
LZ755_RS02540 (LZ755_02540) 533155..533508 + 354 WP_040123277.1 hypothetical protein -
LZ755_RS02545 (LZ755_02545) 533564..533857 - 294 WP_004085592.1 putative addiction module antidote protein -
LZ755_RS02550 (LZ755_02550) 533860..534156 - 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ755_RS02555 (LZ755_02555) 534259..535017 + 759 WP_234492567.1 baseplate J/gp47 family protein -
LZ755_RS02560 (LZ755_02560) 535047..535403 + 357 WP_228762937.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 437715..539257 101542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T230910 WP_024749166.1 NZ_CP090504:c530518-530219 [Xylella fastidiosa subsp. morus]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T230910 NZ_CP125657:877231-877365 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT230910 WP_004085003.1 NZ_CP090504:c530215-529907 [Xylella fastidiosa subsp. morus]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT230910 NZ_CP125657:877002-877154 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References