Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/Fic(toxin) |
| Location | 502986..503674 | Replicon | chromosome |
| Accession | NZ_CP090504 | ||
| Organism | Xylella fastidiosa subsp. morus strain Riv25 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | - |
| Locus tag | LZ755_RS02305 | Protein ID | WP_230577608.1 |
| Coordinates | 503171..503674 (+) | Length | 168 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | A0A060HF63 |
| Locus tag | LZ755_RS02300 | Protein ID | WP_004087046.1 |
| Coordinates | 502986..503174 (+) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ755_RS02255 (LZ755_02255) | 498465..499745 | - | 1281 | WP_234492538.1 | DUF2800 domain-containing protein | - |
| LZ755_RS02260 (LZ755_02260) | 499742..500239 | - | 498 | WP_234492537.1 | hypothetical protein | - |
| LZ755_RS02265 (LZ755_02265) | 500229..500423 | - | 195 | WP_016024078.1 | hypothetical protein | - |
| LZ755_RS02270 (LZ755_02270) | 500455..500646 | - | 192 | WP_040123260.1 | hypothetical protein | - |
| LZ755_RS02275 (LZ755_02275) | 500670..500861 | - | 192 | WP_004087232.1 | hypothetical protein | - |
| LZ755_RS02280 (LZ755_02280) | 500858..501265 | - | 408 | WP_038230230.1 | hypothetical protein | - |
| LZ755_RS02285 (LZ755_02285) | 501262..501732 | - | 471 | WP_038230232.1 | DUF1566 domain-containing protein | - |
| LZ755_RS02290 (LZ755_02290) | 501729..502154 | - | 426 | WP_038230234.1 | hypothetical protein | - |
| LZ755_RS02295 (LZ755_02295) | 502151..502672 | - | 522 | WP_230577609.1 | hypothetical protein | - |
| LZ755_RS02300 (LZ755_02300) | 502986..503174 | + | 189 | WP_004087046.1 | antitoxin VbhA family protein | Antitoxin |
| LZ755_RS02305 (LZ755_02305) | 503171..503674 | + | 504 | WP_230577608.1 | Fic/DOC family protein | Toxin |
| LZ755_RS02310 (LZ755_02310) | 503833..504507 | - | 675 | WP_038230238.1 | helix-turn-helix transcriptional regulator | - |
| LZ755_RS12220 | 504710..504838 | + | 129 | WP_267964465.1 | hypothetical protein | - |
| LZ755_RS02315 (LZ755_02315) | 504828..505325 | + | 498 | WP_234056389.1 | hypothetical protein | - |
| LZ755_RS02320 (LZ755_02320) | 505386..505574 | + | 189 | WP_038230241.1 | hypothetical protein | - |
| LZ755_RS02325 (LZ755_02325) | 505604..505819 | + | 216 | WP_230577607.1 | hypothetical protein | - |
| LZ755_RS02330 (LZ755_02330) | 505837..506058 | + | 222 | WP_234056390.1 | hypothetical protein | - |
| LZ755_RS02335 (LZ755_02335) | 506103..506684 | + | 582 | WP_038230245.1 | Bro-N domain-containing protein | - |
| LZ755_RS02340 (LZ755_02340) | 506750..507859 | + | 1110 | WP_040123376.1 | Bro-N domain-containing protein | - |
| LZ755_RS02345 (LZ755_02345) | 507856..508116 | + | 261 | WP_230577606.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 437715..539257 | 101542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 168 a.a. Molecular weight: 19106.56 Da Isoelectric Point: 6.7262
>T230909 WP_230577608.1 NZ_CP090504:503171-503674 [Xylella fastidiosa subsp. morus]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVS
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVS
Download Length: 504 bp
>T230909 NZ_CP125657:877002-877154 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6855.80 Da Isoelectric Point: 4.9859
>AT230909 WP_004087046.1 NZ_CP090504:502986-503174 [Xylella fastidiosa subsp. morus]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA
Download Length: 189 bp
>AT230909 NZ_CP125657:877231-877365 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|