Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 482566..483171 Replicon chromosome
Accession NZ_CP090504
Organism Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)


Gene name PumA Uniprot ID B2I5N3
Locus tag LZ755_RS02170 Protein ID WP_004089252.1
Coordinates 482875..483171 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LZ755_RS02165 Protein ID WP_038211623.1
Coordinates 482566..482871 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ755_RS02125 (LZ755_02125) 478955..479263 - 309 WP_004085003.1 putative addiction module antidote protein -
LZ755_RS02130 (LZ755_02130) 479267..479566 - 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ755_RS02135 (LZ755_02135) 479654..479959 + 306 WP_230577600.1 hypothetical protein -
LZ755_RS02140 (LZ755_02140) 480103..480423 + 321 WP_234509108.1 hypothetical protein -
LZ755_RS02145 (LZ755_02145) 480423..480740 + 318 WP_012382585.1 hypothetical protein -
LZ755_RS02150 (LZ755_02150) 480737..481567 + 831 WP_234056377.1 hypothetical protein -
LZ755_RS02155 (LZ755_02155) 481564..482205 + 642 WP_040123250.1 Gp138 family membrane-puncturing spike protein -
LZ755_RS02160 (LZ755_02160) 482202..482555 + 354 WP_234056392.1 hypothetical protein -
LZ755_RS02165 (LZ755_02165) 482566..482871 - 306 WP_038211623.1 putative addiction module antidote protein Antitoxin
LZ755_RS02170 (LZ755_02170) 482875..483171 - 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ755_RS02175 (LZ755_02175) 483270..484415 + 1146 WP_038211620.1 baseplate J/gp47 family protein -
LZ755_RS02180 (LZ755_02180) 484412..484972 + 561 WP_004084996.1 DUF2612 domain-containing protein -
LZ755_RS02185 (LZ755_02185) 484976..486139 + 1164 WP_234056379.1 tail fiber protein -
LZ755_RS02190 (LZ755_02190) 486386..487039 + 654 WP_038211241.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 437715..539257 101542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10790.57 Da        Isoelectric Point: 10.0509

>T230908 WP_004089252.1 NZ_CP090504:c483171-482875 [Xylella fastidiosa subsp. morus]
MVELIKTSTFDAWINSLRDRKAAARIQARLDRLALGNPGDVKPVGAGISEMRIDHGPGYRIYFMKHGAVLILLLCGGDKS
SQVRDIEQAKALAALWKD

Download         Length: 297 bp

>T230908 NZ_CP125656:c4693076-4692924 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10982.42 Da        Isoelectric Point: 5.0941

>AT230908 WP_038211623.1 NZ_CP090504:c482871-482566 [Xylella fastidiosa subsp. morus]
MNNETFSRYDTADYLKTEEDIAAYMEAVMEEGGRDNPAFIARALGAVARARNLSQLARDVGMSRQGLDKALSIDGNPSFS
TILKVAKALGLRMSFTPSSMS

Download         Length: 306 bp

>AT230908 NZ_CP125656:c4692847-4692713 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HBK9

Antitoxin

Source ID Structure

References