Detailed information of TA system TA230907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 478955..479566
• Replicon: chromosome
• Accession: NZ_CP090504
• Organism: Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A060HHU8
• Locus tag: LZ755_RS02130
• Protein ID: WP_024749166.1
• Coordinates: 479267..479566 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q879U0
• Locus tag: LZ755_RS02125
• Protein ID: WP_004085003.1
• Coordinates: 478955..479263 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ755_RS02095 (LZ755_02095)	474077..474481	+	405	WP_230577601.1	hypothetical protein	-
LZ755_RS02100 (LZ755_02100)	474482..475978	+	1497	WP_038230289.1	DUF3383 domain-containing protein	-
LZ755_RS02105 (LZ755_02105)	475988..476425	+	438	WP_038230291.1	DUF3277 family protein	-
LZ755_RS02110 (LZ755_02110)	476422..476844	+	423	WP_011097875.1	putative phage tail assembly chaperone	-
LZ755_RS02115 (LZ755_02115)	476871..477035	+	165	WP_014607750.1	hypothetical protein	-
LZ755_RS02120 (LZ755_02120)	476992..478881	+	1890	WP_038230294.1	hypothetical protein	-
LZ755_RS02125 (LZ755_02125)	478955..479263	-	309	WP_004085003.1	putative addiction module antidote protein	Antitoxin
LZ755_RS02130 (LZ755_02130)	479267..479566	-	300	WP_024749166.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ755_RS02135 (LZ755_02135)	479654..479959	+	306	WP_230577600.1	hypothetical protein	-
LZ755_RS02140 (LZ755_02140)	480103..480423	+	321	WP_234509108.1	hypothetical protein	-
LZ755_RS02145 (LZ755_02145)	480423..480740	+	318	WP_012382585.1	hypothetical protein	-
LZ755_RS02150 (LZ755_02150)	480737..481567	+	831	WP_234056377.1	hypothetical protein	-
LZ755_RS02155 (LZ755_02155)	481564..482205	+	642	WP_040123250.1	Gp138 family membrane-puncturing spike protein	-
LZ755_RS02160 (LZ755_02160)	482202..482555	+	354	WP_234056392.1	hypothetical protein	-
LZ755_RS02165 (LZ755_02165)	482566..482871	-	306	WP_038211623.1	putative addiction module antidote protein	-
LZ755_RS02170 (LZ755_02170)	482875..483171	-	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ755_RS02175 (LZ755_02175)	483270..484415	+	1146	WP_038211620.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	437715..539257	101542

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-98)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11364.14 Da
• Isoelectric Point: 10.3861

>T230907 WP_024749166.1 NZ_CP090504:c479566-479267 [Xylella fastidiosa subsp. morus]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Nucleotide

• Length: 300 bp

>T230907 NZ_CP125656:c4692847-4692713 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11060.61 Da
• Isoelectric Point: 4.6535

>AT230907 WP_004085003.1 NZ_CP090504:c479263-478955 [Xylella fastidiosa subsp. morus]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Nucleotide

• Length: 309 bp

>AT230907 NZ_CP125656:c4693076-4692924 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Structures

Toxin

• AlphaFold DB: A0A060HHU8

Antitoxin

• AlphaFold DB: A0A060HCD4