Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2502870..2504419 Replicon chromosome
Accession NZ_CP090495
Organism Photobacterium damselae subsp. damselae strain AS-15-0759-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IHC89_RS11770 Protein ID WP_237031128.1
Coordinates 2503118..2504419 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IHC89_RS11765 Protein ID WP_036764367.1
Coordinates 2502870..2503118 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHC89_RS11735 (IHC89_11735) 2498316..2499983 + 1668 WP_237031126.1 DNA repair protein RecN -
IHC89_RS11740 (IHC89_11740) 2500239..2500595 + 357 WP_036765125.1 outer membrane protein assembly factor BamE -
IHC89_RS11745 (IHC89_11745) 2500701..2500997 - 297 WP_036764354.1 RnfH family protein -
IHC89_RS11750 (IHC89_11750) 2500987..2501421 - 435 WP_036764355.1 SRPBCC family protein -
IHC89_RS11755 (IHC89_11755) 2501615..2502097 + 483 WP_237031127.1 SsrA-binding protein SmpB -
IHC89_RS11765 (IHC89_11765) 2502870..2503118 + 249 WP_036764367.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IHC89_RS11770 (IHC89_11770) 2503118..2504419 + 1302 WP_237031128.1 type II toxin-antitoxin system HipA family toxin Toxin
IHC89_RS11775 (IHC89_11775) 2504643..2504975 + 333 Protein_2185 hypothetical protein -
IHC89_RS11780 (IHC89_11780) 2505085..2506551 - 1467 WP_237031129.1 3'-5' exonuclease -
IHC89_RS11785 (IHC89_11785) 2506792..2506953 - 162 WP_237031130.1 hypothetical protein -
IHC89_RS11790 (IHC89_11790) 2507134..2507709 + 576 WP_106142169.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48738.47 Da        Isoelectric Point: 8.7938

>T230905 WP_237031128.1 NZ_CP090495:2503118-2504419 [Photobacterium damselae subsp. damselae]
MQKLIAYMNGELVGTLEKHKNGAHTFQYDKNWLTNAVTRPLSLSLKLQLPAITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDNVGAIALLPPDRPYKKEPLSYEVLDNKKLETVLSAYKSDIPLGMLEKEEDFRISVAGVQEKTAL
LFVDEQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARALGFAVPNVNIIQTDNIKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMELLMGSSNALEDRYNFMRFQVFQWLIGATDGHAKNFSIYID
KGGSYRLTPFYDILSAYPLLGGKGLNIRKLKLAMGLKATKGKKYEISKILPRHFLDTAKDVNFNQDTMQEIIDEMKDALP
KAMLQVSATLPKGFPEHIVGSIFENTQKIVKKI

Download         Length: 1302 bp

>T230905 NZ_CP125656:43464-43619 [Xanthomonas campestris]
GTGACCCTGCTCGATACCAATGTCATCTTCGGGCCCAATCTGCATGTCGTCGCCTGGATCGATGTGCAGGCCGTTGAAAC
ACTGTTCCTGTCGGTCGTGACGGTGGCCGAATTGCGATCTGGAGACATTCAGGATTTCAGACCCCTGATGAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9351.69 Da        Isoelectric Point: 6.2564

>AT230905 WP_036764367.1 NZ_CP090495:2502870-2503118 [Photobacterium damselae subsp. damselae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKSQVASLNENDDE
SW

Download         Length: 249 bp

>AT230905 NZ_CP125656:43213-43467 [Xanthomonas campestris]
ATGCCTTCTTTCACCGTCCGCAACATCCCGGAGGATGTGCATCGCGCCATCTGGGCACGTGCTGCCCAACACGGGCGCAG
CACCGAGGCGGAGATCCGCGCGATCCTTGAATCAGCAGCCAAGCCAGCCGACCAGGTCAAACTTGGCGCGTTGCTGGTGG
ACATCGGCCGCGACGCTGGCCTGACAGCAAAAGAGGCCGACGCCTTCGCCAAGTTACGCGACAAGGCCGCGATCAAGCCG
ATCGGTTTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References