Detailed information of TA system TA230902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 748814..749363
• Replicon: chromosome
• Accession: NZ_CP090486
• Organism: Photobacterium damselae subsp. damselae strain AS-16-0963-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IHC93_RS18390
• Protein ID: WP_112163365.1
• Coordinates: 748814..749113 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4S2JEC7
• Locus tag: IHC93_RS18395
• Protein ID: WP_068969759.1
• Coordinates: 749121..749363 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHC93_RS18365 (IHC93_18365)	745246..746937	+	1692	WP_237041666.1	galactosyl transferase	-
IHC93_RS18370 (IHC93_18370)	747056..747595	+	540	WP_237041667.1	NUDIX hydrolase	-
IHC93_RS18375 (IHC93_18375)	747599..747814	+	216	WP_109375442.1	DUF3820 family protein	-
IHC93_RS18380 (IHC93_18380)	747825..748313	+	489	WP_106141836.1	leucine-rich repeat domain-containing protein	-
IHC93_RS18385 (IHC93_18385)	748388..748768	-	381	WP_237041668.1	hypothetical protein	-
IHC93_RS18390 (IHC93_18390)	748814..749113	-	300	WP_112163365.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IHC93_RS18395 (IHC93_18395)	749121..749363	-	243	WP_068969759.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IHC93_RS18400 (IHC93_18400)	749509..750804	-	1296	WP_068945734.1	DEAD/DEAH box helicase	-
IHC93_RS18405 (IHC93_18405)	750980..751402	-	423	WP_005304250.1	DUF3010 family protein	-
IHC93_RS18410 (IHC93_18410)	751550..752005	+	456	WP_237041669.1	DUF2559 family protein	-
IHC93_RS18415 (IHC93_18415)	751998..752600	+	603	WP_237041670.1	putative adenosine monophosphate-protein transferase Fic	-
IHC93_RS18420 (IHC93_18420)	752754..753104	-	351	WP_068945731.1	hypothetical protein	-
IHC93_RS18425 (IHC93_18425)	753175..753681	-	507	WP_044179650.1	M48 family metallopeptidase	-
IHC93_RS18430 (IHC93_18430)	753788..754240	+	453	WP_036765420.1	isoprenylcysteine carboxylmethyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-48)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11514.29 Da
• Isoelectric Point: 9.3232

>T230902 WP_112163365.1 NZ_CP090486:c749113-748814 [Photobacterium damselae subsp. damselae]
MYKSRYKLSQLAQTHLRKIKSYTTENFSELQWSNYKAILISGFQMLADNPDLGKHCADIYPNGFYFPIGKHIVFFTKEDD
FILVVAVLGQTQLPQNHLK

Nucleotide

• Length: 300 bp

>T230902 NZ_CP125654:c1242122-1241376 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8971.21 Da
• Isoelectric Point: 6.4589

>AT230902 WP_068969759.1 NZ_CP090486:c749363-749121 [Photobacterium damselae subsp. damselae]
MRTLSANDAKRHFGELLLNAQRGPVKISKNRKDAVVVMSIQDFEELEAMKVEYLTHCFKSAKEDLNNGTAVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT230902 NZ_CP125654:c1241375-1241205 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A4S2JEC7