Detailed information of TA system TA230897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2792144..2792764
• Replicon: chromosome
• Accession: NZ_CP090484
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LXM88_RS34635
• Protein ID: WP_096474909.1
• Coordinates: 2792447..2792764 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1J9PWC2
• Locus tag: LXM88_RS34630
• Protein ID: WP_039344756.1
• Coordinates: 2792144..2792443 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS34600 (LXM88_34540)	2788119..2788595	+	477	WP_014900133.1	anthranilate 1,2-dioxygenase small subunit AndAd	-
LXM88_RS34605 (LXM88_34545)	2788613..2788939	+	327	WP_096474914.1	anthranilate 1,2-dioxygenase ferredoxin subunit AndAb	-
LXM88_RS34610 (LXM88_34550)	2788929..2790149	+	1221	WP_262543980.1	anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase	-
LXM88_RS34615 (LXM88_34555)	2790361..2791647	+	1287	WP_262543981.1	DUF445 domain-containing protein	-
LXM88_RS34620 (LXM88_34560)	2791681..2791983	-	303	WP_257770678.1	HigA family addiction module antitoxin	-
LXM88_RS34625 (LXM88_34565)	2791996..2792148	-	153	Protein_2478	type II toxin-antitoxin system RelE/ParE family toxin	-
LXM88_RS34630 (LXM88_34570)	2792144..2792443	-	300	WP_039344756.1	putative addiction module antidote protein	Antitoxin
LXM88_RS34635 (LXM88_34575)	2792447..2792764	-	318	WP_096474909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LXM88_RS34640 (LXM88_34580)	2793115..2794755	+	1641	WP_262543982.1	acetolactate synthase large subunit	-
LXM88_RS34645 (LXM88_34585)	2794785..2796218	+	1434	WP_262543983.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-91)

Antitoxin

• Uncharacterized protein HI1420 (6-93)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11838.57 Da
• Isoelectric Point: 9.5691

>T230897 WP_096474909.1 NZ_CP090484:c2792764-2792447 [Burkholderia sp. S-53]
MPYSAPTFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLAHLDME

Nucleotide

• Length: 318 bp

>T230897 NZ_CP125651:c543364-542954 [Rhizobium sp. BT04]
GTGATCACACATCTTATCGACACCAATGCGGTGATCGCTCTGATCGGCAGGAAATCCGAAACACTGCTGAAGCGCGTGAT
CGACAACGACGAGGGATCGATCGGGCTTTCGACCGTGGTGATGCACGAGCTCTATTATGGCGCCTATAAAAGCGCGAAGA
TCTCCTACAATCTCGAAACGCTGCGCCTGTTCATGGCAGAGTTCTCAGTCATCGGTTTCGAGCAGGAGGATGCGTTAGCC
GCTGGGAAGATCCGTGCCGCATTGGCGACAAAGGGAACGCCGATCGGTCCCTATGATGTCCTGATCGCCGCCCAGGCCAG
GACCCGGGATCTGGTTCTCGTCACCAACAATGTCGGGGAATTCCGCCGCGTCGATGGCCTGCGTGTCGAGGACTGGACGG
TCGGGCGGTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10649.01 Da
• Isoelectric Point: 6.3217

>AT230897 WP_039344756.1 NZ_CP090484:c2792443-2792144 [Burkholderia sp. S-53]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Nucleotide

• Length: 300 bp

>AT230897 NZ_CP125651:c543621-543361 [Rhizobium sp. BT04]
ATGCCGCAATATGCGCGTGTATTTCAATCCGGCAATTCGCAAGCCGTCCGGCTGCCGAAAGAGTTCCGCTTCGACGTCGA
CCAGGTGGAGGTGACGCGGGAAGGCGATGCTGTCATTCTTCGGCCACGGGCCGAGCGCGGCGTGCGGTGGGCATCGTTGC
ATAGCGCCTTGGAGCGCGGCCTCAGCGACGATTTCATGGCGGAAGGGCGAGAGCAGCCGGAGGGGCAGGAGCGGCCTGAT
CTTCAGGACCTGTTCAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9PWC2