Detailed information of TA system TA230896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1589494..1590013
• Replicon: chromosome
• Accession: NZ_CP090484
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: LXM88_RS29235
• Protein ID: WP_262546725.1
• Coordinates: 1589494..1589775 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0G3WYJ8
• Locus tag: LXM88_RS29240
• Protein ID: WP_047902230.1
• Coordinates: 1589765..1590013 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS29215 (LXM88_29160)	1585173..1585871	-	699	WP_262546717.1	MgtC/SapB family protein	-
LXM88_RS29220 (LXM88_29165)	1585986..1587095	+	1110	WP_262546719.1	AGE family epimerase/isomerase	-
LXM88_RS29225 (LXM88_29170)	1587068..1588687	-	1620	WP_262546721.1	methyl-accepting chemotaxis protein	-
LXM88_RS29230 (LXM88_29175)	1588994..1589437	+	444	WP_262546722.1	PaaI family thioesterase	-
LXM88_RS29235 (LXM88_29180)	1589494..1589775	-	282	WP_262546725.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LXM88_RS29240 (LXM88_29185)	1589765..1590013	-	249	WP_047902230.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LXM88_RS29245 (LXM88_29190)	1590132..1591184	-	1053	WP_262546727.1	CaiB/BaiF CoA-transferase family protein	-
LXM88_RS29250 (LXM88_29195)	1591508..1592701	-	1194	WP_262546728.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10928.82 Da
• Isoelectric Point: 10.2231

>T230896 WP_262546725.1 NZ_CP090484:c1589775-1589494 [Burkholderia sp. S-53]
MTFELAFLEAALKEWKKLDRTVRDQFKARLAERLENPRIPSAKLHGHPDRYKIKLCSVGYRLVYEVRDAEVVVLVVEVGR
RERDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T230896 NZ_CP125647:78749-79039 [Rhizobium sp. BT04]
ATGCTACAAGTAGTCTTCTCCCCCGCCGCAATCCGCGACCTTGAGCGGCTCCGGGAGTTCTTACGGCTGAAAAACCCATC
GGCCGCGAAGCGAGCAGCCGAAACTATCCTCAACGGCTTGAGAGTCCTCGGCGCACATCCCCATATTGGACGCCTCATCG
AGGACTTGCCTGAGCAATACCGGGAGTTGCTCATCGATTTTGGAGATAGTGGATACGTCGCCCGTTATCGTATTGATGGC
GCCATTTTGACGATCCTCGCCGTACGGCATCAGAAGGAAGCAGGGTTCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8935.26 Da
• Isoelectric Point: 5.0636

>AT230896 WP_047902230.1 NZ_CP090484:c1590013-1589765 [Burkholderia sp. S-53]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAKEKAVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT230896 NZ_CP125647:78483-78761 [Rhizobium sp. BT04]
ATGGCATCGCCAACCTCGCTCAAGCTCGATGATGAGCTAAAGGGCCGCGTTCAGCAACTGGCCGAAGCTCGCCGCCGCTC
GTCCCACTGGATCATGCGTGAAGCTATCGCGCAATATGTTGAGCGCGAAGAGAAGCGCGAGGCACTGCGGCAGGAGACGC
TTGACGCCTGGAATGAATTTAAAGCGACGGGACTGCATGTCACGGGCGCCGAGGTCGAAAAATGGCTTTCGACTTGGGGA
ACTGACGAGGAATTGTCCGCACCCGAATGCTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0G3WYJ8