Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 926252..927470 Replicon chromosome
Accession NZ_CP090484
Organism Burkholderia sp. S-53

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXM88_RS26365 Protein ID WP_262545594.1
Coordinates 926889..927470 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LXM88_RS26360 Protein ID WP_262545592.1
Coordinates 926252..926809 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM88_RS26340 (LXM88_26290) 922116..922847 - 732 WP_262545586.1 ribonuclease T2 -
LXM88_RS26345 (LXM88_26295) 923097..923675 - 579 WP_262545587.1 hypothetical protein -
LXM88_RS26350 (LXM88_26300) 923770..925170 - 1401 WP_262545589.1 DUF308 domain-containing protein -
LXM88_RS26355 (LXM88_26305) 925529..926167 + 639 WP_262545590.1 hypothetical protein -
LXM88_RS26360 (LXM88_26310) 926252..926809 + 558 WP_262545592.1 helix-turn-helix transcriptional regulator Antitoxin
LXM88_RS26365 (LXM88_26315) 926889..927470 + 582 WP_262545594.1 HD domain-containing protein Toxin
LXM88_RS26370 (LXM88_26320) 927757..928950 + 1194 WP_262545596.1 efflux RND transporter periplasmic adaptor subunit -
LXM88_RS26375 (LXM88_26325) 928953..930977 + 2025 WP_262545598.1 MacB family efflux pump subunit -
LXM88_RS26380 (LXM88_26330) 930990..932363 + 1374 WP_262545599.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-171)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21375.94 Da        Isoelectric Point: 5.2900

>T230895 WP_262545594.1 NZ_CP090484:926889-927470 [Burkholderia sp. S-53]
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERNDLLTLTSSLDRTLRDEIVALWEEYDAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSTIRDIVDADTQRRIDAGGHRA

Download         Length: 582 bp

>T230895 NZ_CP125644:c234072-233650 [Rhizobium sp. BT03]
GTGAAGCTTCTGCTGGACACCAATGTCCTGTCCGAGGTGACGAAGCCGAGCCCTGATGCGCGCGTCTTGCAGTGGCTGGA
CAGGCTCGACGAGGATCGCGCCTTCGTCAGCATCGTGTCGGTCGCCGAGATCCGGCGCGGCGTTGCCCTGATGGACAAGG
GGCGGAAACGCGATGCGCTGGCCGAATGGCTTGCCCAGGACCTGACCCAACGCTTCGAGCACCGCATCATTCCGGTGGAT
GAACCGGTTGCGCTGGCCTGGGGAGACCTCATGGGCCACGCAAAGCCAAGCGGCCGCGGTCTGTCGTCGATGGACGGCCT
GATCGCGGCGACCGCGATTGCTCACGATCTCAGCCTCGCCACACGCAACACCAGGGATTTCGAGGGCTTTGGGATCGAAC
TCATCGATCCCTGGATCGTATAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20130.01 Da        Isoelectric Point: 11.0994

>AT230895 WP_262545592.1 NZ_CP090484:926252-926809 [Burkholderia sp. S-53]
MTASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSADERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPTLLGTSLWRYATPEIVRMETALDTLGWRDRAGPPSVEFATGTNASRVVP
IRGSTCRWTRMTLSDGSASRLVETL

Download         Length: 558 bp

>AT230895 NZ_CP125644:c234335-234069 [Rhizobium sp. BT03]
ATGCGGCTATCAAAGCAAGGCGATGAAAGCTGGACTGTTGCCAGTGCAAAGGCGAAGCTTTCCGAGGTGATCGAACGCGC
GCAATCCGCGCCGCAGACAATCACACGAAACGGCAAACCGAGCGTCATCGTCGTTTCTGCGGAGGAATGGCAGCGCAAGA
CCGCGCGCAAGGGGACGCTTGCCGAGTTTCTGATGGAATCGCCGCTGCGCGGCGCCGATCTGGATCTTGAGCGGCAGCGC
GACGAGCCGCGTGATCCCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References