Detailed information of TA system TA230894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 832339..832862
• Replicon: chromosome
• Accession: NZ_CP090484
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q399A4
• Locus tag: LXM88_RS25930
• Protein ID: WP_011354451.1
• Coordinates: 832596..832862 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LXM88_RS25925
• Protein ID: WP_262545466.1
• Coordinates: 832339..832599 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS25905 (LXM88_25855)	828356..829744	+	1389	WP_262545420.1	MFS transporter	-
LXM88_RS25910 (LXM88_25860)	830147..831358	+	1212	WP_262545422.1	crosslink repair DNA glycosylase YcaQ family protein	-
LXM88_RS25915 (LXM88_25865)	831394..831612	-	219	WP_006480837.1	DUF1653 domain-containing protein	-
LXM88_RS25920 (LXM88_25870)	831670..832113	-	444	WP_262545465.1	GNAT family N-acetyltransferase	-
LXM88_RS25925 (LXM88_25875)	832339..832599	+	261	WP_262545466.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LXM88_RS25930 (LXM88_25880)	832596..832862	+	267	WP_011354451.1	Txe/YoeB family addiction module toxin	Toxin
LXM88_RS25935 (LXM88_25885)	833094..833924	+	831	WP_262545467.1	substrate-binding domain-containing protein	-
LXM88_RS25940 (LXM88_25890)	833942..834565	+	624	WP_262545468.1	HAD hydrolase-like protein	-
LXM88_RS25945 (LXM88_25895)	834956..835525	+	570	WP_262545470.1	DUF4142 domain-containing protein	-
LXM88_RS25950 (LXM88_25900)	835662..836261	-	600	WP_262545471.1	GNAT family protein	-
LXM88_RS25955 (LXM88_25905)	836318..837232	-	915	WP_262545472.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.86 Da
• Isoelectric Point: 7.9861

>T230894 WP_011354451.1 NZ_CP090484:832596-832862 [Burkholderia sp. S-53]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Nucleotide

• Length: 267 bp

>T230894 NZ_CP125644:191952-192242 [Rhizobium sp. BT03]
ATGCCGCAAGTAATCTTCTCTCCGGCCGCAATCCGCGACCTCAAGCGGCTGCGGGAGTTCCTGCGGCCGAAAAACCCGTC
GGTCGCCAAGCGGGCAGGCGAAACCATTCTCAAAGGCGTGAGCCTCCTCGGCACGCATCCCCATATGGGACGCCTCATCG
AAAACTTGCCCGAGCAATATCGGGAATGGCTCATCGATTTCGGAGAGAGCGGATACGTCGCGCGTTATCGTGTGGATGGC
GACATTTTGACGATCCTCGCCGTGCGGCACCAGAAGGAAGCAGGGTTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9789.05 Da
• Isoelectric Point: 6.0717

>AT230894 WP_262545466.1 NZ_CP090484:832339-832599 [Burkholderia sp. S-53]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRTPANVAHLERSIAQLRKGKTKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT230894 NZ_CP125644:191686-191964 [Rhizobium sp. BT03]
ATGGCATCGCCGACCTCGCTCAAGCTCGATGATGAGCTGAAGGGCCGCGTCCAACAACTGGCCGAGGCTCGCCGCCGTTC
GTCCCACTGGATCATGCGTGAAGCTATTGCGCAATATGTCGAGCGCGAGGAGAAGCGCGAGACGCTGCGGCAGGAGACGC
TTGACGCCTGGAAGGAATTTGAAGCGACGGGACTGCACGTCACCGGCGTCGAGGTCGAAAAGTGGCTTTCGACCTGGGGA
ACTGACGACGAGTCGTCCGCCCCCGAATGCCGCAAGTAA

Structures

Toxin

• AlphaFold DB: A0A1J9NJ39