Detailed information of TA system TA230893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 750665..751320
• Replicon: chromosome
• Accession: NZ_CP090484
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LXM88_RS25585
• Protein ID: WP_262545349.1
• Coordinates: 750665..751084 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2S8IH63
• Locus tag: LXM88_RS25590
• Protein ID: WP_034180974.1
• Coordinates: 751081..751320 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS25560 (LXM88_25510)	745992..746786	+	795	WP_262545341.1	AraC family transcriptional regulator	-
LXM88_RS25565 (LXM88_25515)	747032..747991	+	960	WP_262545342.1	DMT family transporter	-
LXM88_RS25570 (LXM88_25520)	748197..748769	+	573	WP_262545343.1	permease	-
LXM88_RS25575 (LXM88_25525)	748870..749004	-	135	WP_009688930.1	entericidin A/B family lipoprotein	-
LXM88_RS25580 (LXM88_25530)	749238..750533	+	1296	WP_262545348.1	aspartate carbamoyltransferase	-
LXM88_RS25585 (LXM88_25535)	750665..751084	-	420	WP_262545349.1	type II toxin-antitoxin system VapC family toxin	Toxin
LXM88_RS25590 (LXM88_25540)	751081..751320	-	240	WP_034180974.1	Arc family DNA-binding protein	Antitoxin
LXM88_RS25595 (LXM88_25545)	751632..753875	+	2244	WP_262545350.1	TonB-dependent siderophore receptor	-
LXM88_RS25600 (LXM88_25550)	753879..754634	+	756	WP_262545351.1	tetratricopeptide repeat protein	-
LXM88_RS25605 (LXM88_25555)	754631..755314	+	684	WP_262545352.1	Fe2+-dependent dioxygenase	-
LXM88_RS25610 (LXM88_25560)	755395..755817	-	423	WP_262545353.1	amino acid-binding protein	-
LXM88_RS25615 (LXM88_25565)	756024..756263	+	240	WP_048245635.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15230.59 Da
• Isoelectric Point: 7.0193

>T230893 WP_262545349.1 NZ_CP090484:c751084-750665 [Burkholderia sp. S-53]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEIRFGVAVMPEGRRREWLHRSIEQRVVPLFRGRILPFDD
AASKAYASVRARARVAGNAIAPVDGFIAATADANGLIVATRDVAPFEAVGLRVIDPWAR

Nucleotide

• Length: 420 bp

>T230893 NZ_CP125641:403754-404179 [Rhizobium sp. BT03]
ATGATTATCCTCGATACGAACGTCGTTTCCGAGGCGATGAAACCCGCGCCCGACGACGCCGTGAAATTCTGGCTCGATGA
GCAGGCAGCCGAAACCCTCTTCCTTTCCAGCGTCACGATCGCCGAACTGATGTTTGGCATTGGCGCGCTCCCGGCCGGCA
AACGCAAGGAAAGACTATCCGACGCGTTGGACGGTTTGGAGGAGCTGTTCGAAGGCCGCATTCTGGCCTTCGACATCACC
GCCGCACGACACTATGCCGATCTCGCTGTCAAAGCCCGAGCCGCGGGCAGAGGCTTCCCTACTCCGGATGGTTATATCGC
CGCCATCGCGGCATCGAAGGGATTCGTCGTCGCCACGCGCGATACAAGTGCCTTCGACGCGGCAGGTGTCGAGGTGATCA
ATCCTTGGGCCACTTCGCGCGCATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8707.89 Da
• Isoelectric Point: 5.6864

>AT230893 WP_034180974.1 NZ_CP090484:c751320-751081 [Burkholderia sp. S-53]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVDFDVQRDKTSTDPMSFE

Nucleotide

• Length: 240 bp

>AT230893 NZ_CP125641:403503-403757 [Rhizobium sp. BT03]
ATGCCCGCAGTCACAATCAGAAACCTCTCCGAGGCGACGCACCGGGCCCTCAAGGTGCGCGCGGCCCATCACGGGCGCAG
CGCCGAAGCGGAAATGCGCGAAATCCTCGAAGCTGCCGTCCGTCCAGAAACGCGGCTGCGTCTTGGCAGCGCGCTCGCCG
AACGGAGCCGTCTCCTCGGGCTGACGAATGACGACTTTGCCGTTCTGGACCAGGCTTTCGACAAAATCCCTGCGAAGCCG
ATGAGCTTTGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S8IH63