Detailed information of TA system TA230892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 612834..614584
• Replicon: chromosome
• Accession: NZ_CP090484
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LXM88_RS24900
• Protein ID: WP_262545154.1
• Coordinates: 613688..614584 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: LXM88_RS24895
• Protein ID: WP_262545152.1
• Coordinates: 612834..613691 (-)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS24875 (LXM88_24825)	608009..609499	-	1491	WP_262545146.1	aldehyde dehydrogenase	-
LXM88_RS24880 (LXM88_24830)	609572..610387	-	816	WP_262545147.1	aspartate dehydrogenase	-
LXM88_RS24885 (LXM88_24835)	610380..612047	-	1668	WP_262545148.1	thiamine pyrophosphate-binding protein	-
LXM88_RS24890 (LXM88_24840)	612040..612837	-	798	WP_262545150.1	SDR family oxidoreductase	-
LXM88_RS24895 (LXM88_24845)	612834..613691	-	858	WP_262545152.1	IclR family transcriptional regulator	Antitoxin
LXM88_RS24900 (LXM88_24850)	613688..614584	-	897	WP_262545154.1	alpha/beta fold hydrolase	Toxin
LXM88_RS24905 (LXM88_24855)	614603..615130	-	528	WP_006489904.1	cupin domain-containing protein	-
LXM88_RS24910 (LXM88_24860)	615160..615930	-	771	WP_262545166.1	SDR family oxidoreductase	-
LXM88_RS24915 (LXM88_24865)	615923..616993	-	1071	WP_262545167.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
LXM88_RS24920 (LXM88_24870)	617049..617360	-	312	WP_034180372.1	hypothetical protein	-
LXM88_RS24925 (LXM88_24875)	617362..617679	-	318	WP_027789384.1	non-heme iron oxygenase ferredoxin subunit	-
LXM88_RS24930 (LXM88_24880)	618127..619206	+	1080	WP_262545168.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-279)

Antitoxin

• Transcription regulator IclR, C-terminal (143-266)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30576.80 Da
• Isoelectric Point: 8.0625

>T230892 WP_262545154.1 NZ_CP090484:c614584-613688 [Burkholderia sp. S-53]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPGRIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDTQRGLV

Nucleotide

• Length: 897 bp

>T230892 NZ_CP125641:152755-153030 [Rhizobium sp. BT03]
ATGGAACTCAAATGGACGAGCAAAGCGGTCTCGGACATTGACCGCCTCTATGCCTTTCTCGCTCCGGTCAATCGACAGGC
GGCGGCTCGGACTGTGCAGGCCTTGACGGCAGCGCCGCTGCGACTGCTTGAGCAGCCGCGCCTTGGCGAGCGGCTGGAGG
AGTTCGATCCTCGGGAGGTCCGCCGCATTCTCGTTGGTCACTACGAGCTACGTTATGAAATACGGCAGTCGGCCATCTAT
GTATTGCGGCTCTGGCATACGCGTGAAGACCGGTAA

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31447.04 Da
• Isoelectric Point: 6.9861

>AT230892 WP_262545152.1 NZ_CP090484:c613691-612834 [Burkholderia sp. S-53]
MSEPLQQQESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPQGMLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 858 bp

>AT230892 NZ_CP125641:152495-152755 [Rhizobium sp. BT03]
ATGGAAACCAAAGTGCTGACTGCGCATGTTCCCCTGCCCCTTGCGCAAAAGGTCGATCAACTCGCCGCAAGGCTTGAGCG
CTCGCGCGGCTGGATCGTCAAGCAGGCGCTGACGGCATGGATCGATCAGGAGGAGGAGCGTCGCCGTTTGACGCTGGAAG
CGCTGGCTGATGTGGATGAAGGCAAAGTGGTCGATCATCAGTCCGTCCAGGCCTGGGCCGATAGTCTCGACAGTGACGCG
CCGGTTTCGTTGCCTCGCTAA