Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 382208..382847 Replicon chromosome
Accession NZ_CP090484
Organism Burkholderia sp. S-53

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXM88_RS23890 Protein ID WP_262544916.1
Coordinates 382208..382624 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LXM88_RS23895 Protein ID WP_262544917.1
Coordinates 382611..382847 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM88_RS23865 (LXM88_23815) 377318..378406 - 1089 WP_262544911.1 nitronate monooxygenase -
LXM88_RS23870 (LXM88_23820) 378403..379323 - 921 WP_262544912.1 enoyl-CoA hydratase -
LXM88_RS23875 (LXM88_23825) 379332..380129 - 798 WP_262544913.1 ketoacid CoA transferase -
LXM88_RS23880 (LXM88_23830) 380140..381033 - 894 WP_262544914.1 CoA-transferase -
LXM88_RS23885 (LXM88_23835) 381043..381939 - 897 WP_262544915.1 VOC family protein -
LXM88_RS23890 (LXM88_23840) 382208..382624 - 417 WP_262544916.1 type II toxin-antitoxin system VapC family toxin Toxin
LXM88_RS23895 (LXM88_23845) 382611..382847 - 237 WP_262544917.1 DNA-binding protein Antitoxin
LXM88_RS23900 (LXM88_23850) 383924..384697 - 774 WP_262544918.1 SDR family oxidoreductase -
LXM88_RS23905 (LXM88_23855) 384730..386310 - 1581 WP_262546905.1 FadD3 family acyl-CoA ligase -
LXM88_RS23910 (LXM88_23860) 386358..387401 - 1044 WP_262544919.1 ferredoxin--NADP reductase -
LXM88_RS23915 (LXM88_23865) 387412..387639 - 228 WP_262544921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hsiC1/vipB 59806..598081 538275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15471.75 Da        Isoelectric Point: 7.4039

>T230891 WP_262544916.1 NZ_CP090484:c382624-382208 [Burkholderia sp. S-53]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHRQASALEAWMATILSGYAPNL
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 417 bp

>T230891 NZ_CP125640:3833666-3834049 [Rhizobium sp. BT03]
GTGATCTTGGCAGACACTTCGATCTGGATTGACCATTTCCGACATGCCGATGCAGAGCTACGCAGAATTATTGAAGACGA
TCGGCTGCTTTGCCATCCGAGCGTGATCGGCGAGTTGGCTCTCGGCAGCCTTAGGGATCGCGACAGGGTGATGGCCTTCC
TGGCGGCTCAGCGCGGAGCGGTTGTCGCGACGCACGATGAAGTCATGACCATGATCAATCGGTATGGCATTTTCAGCATG
GGCATCGGCTACACCGATGCTCACTTGCTGGCGTCCGTTCTTCTTGAACGGAGAGCGACGCTATGGACCAGGGACAAGCG
GCTGCGGCTAGCGGCCGAAAAAGCGGGCGTCTCATTGCACATACCGGTCAACACGCCCCGCTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8724.81 Da        Isoelectric Point: 5.0628

>AT230891 WP_262544917.1 NZ_CP090484:c382847-382611 [Burkholderia sp. S-53]
MANLLVRNVDDILVQSLREQAAANGRSAEAEHRAILADALGRPKRRTFAQVLMSMPDVGEDTDFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT230891 NZ_CP125640:3833469-3833669 [Rhizobium sp. BT03]
ATGCGATCCACGATCAATCTCGATGACGCACTCATGGATAGGGCGAAGTCTTTGACCGGCATTAAGGAAACCGCAGCTCT
CGTCCGACAAGCGTTGGAAACGCTTGTTCGCGTAGAGTCCGGAAAGCGCCTCATCGCACTCGGAGGAACCATGCCGGATG
CCGAGGCAGCCCCGCGCCGCCGGAGCGCAGCAGTTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References