Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 198229..198862 Replicon chromosome
Accession NZ_CP090484
Organism Burkholderia sp. S-53

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXM88_RS23095 Protein ID WP_262544653.1
Coordinates 198449..198862 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LXM88_RS23090 Protein ID WP_262544652.1
Coordinates 198229..198462 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM88_RS23080 (LXM88_23030) 194900..197200 + 2301 WP_262544650.1 ATP-dependent DNA helicase -
LXM88_RS23085 (LXM88_23035) 197300..198070 - 771 WP_262544651.1 IclR family transcriptional regulator C-terminal domain-containing protein -
LXM88_RS23090 (LXM88_23040) 198229..198462 + 234 WP_262544652.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LXM88_RS23095 (LXM88_23045) 198449..198862 + 414 WP_262544653.1 PIN domain-containing protein Toxin
LXM88_RS23100 (LXM88_23050) 198905..199300 - 396 WP_262547107.1 DUF4440 domain-containing protein -
LXM88_RS23105 (LXM88_23055) 199603..200091 + 489 WP_262544654.1 hypothetical protein -
LXM88_RS23110 (LXM88_23060) 200220..201521 - 1302 WP_047903294.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
LXM88_RS23115 (LXM88_23065) 201725..203032 - 1308 WP_262547109.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hsiC1/vipB 59806..598081 538275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15240.39 Da        Isoelectric Point: 4.9468

>T230889 WP_262544653.1 NZ_CP090484:198449-198862 [Burkholderia sp. S-53]
MSGIESAKSFVDSNVVLYLLSEDETKADRAEALFLRRPTISVQVLNEVASVCSRKLRMPWSDVGQFLEPIRSLCHVVPVT
IDTHDLARRLAERHGLSFYDACIVAAASLEGCEYLYTEDMHDGLRVDGGPVLRNPFA

Download         Length: 414 bp

>T230889 NZ_CP125640:c1565706-1565437 [Rhizobium sp. BT03]
ATGGCGTGGAGAATTGAGTTTCAAAGAGCAGCCGAGCGCGAGCTTGAGAAACTCGGACATGAGGCGGCTCGCCGAATACT
CCGATTTCTCAACGATCGCGTCGCAAGGCTGGACGACCCACGATCCATTGGAGAGGCGCTTAAAGGGTCTGAACTCGGGG
ATTTCTGGAAATATCGCGTTGGCGACTATCGAGTGATCGCAAGCATCGATGACGGAGCCGTTCGTATCCTCGTCGTGCGT
ATCGGAAACCGCCGCGACGTCTACCGGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8809.03 Da        Isoelectric Point: 8.8306

>AT230889 WP_262544652.1 NZ_CP090484:198229-198462 [Burkholderia sp. S-53]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRADELLQRLRRFRGKLPADFKFSRDDANERD

Download         Length: 234 bp

>AT230889 NZ_CP125640:c1565914-1565690 [Rhizobium sp. BT03]
ATGTTGGCTTTGCGGTTGCCGCCTGAAATCGAAGCCCGGCTCGACGAGCTTTCCAAGCGCACGGGCCGCAGCAAGAGCTT
CTATGCCCGTCAGGCCATTCTCGAACATCTCGATGACCTCGAGGATGTCTATCTCGCCGAAAAGCGTCTTGAAGAACTTC
GGCGAGGTGAGGGTGATACCGTTTCGCTGGCCGAGCTGATGACGCGTTATGGCGTGGAGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References