Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1850750..1851284 Replicon chromosome
Accession NZ_CP090483
Organism Burkholderia sp. S-53

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LXM88_RS13490 Protein ID WP_262531665.1
Coordinates 1850985..1851284 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LXM88_RS13485 Protein ID WP_262531664.1
Coordinates 1850750..1850995 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM88_RS13460 (LXM88_13425) 1845992..1846408 + 417 WP_027787436.1 PIN domain-containing protein -
LXM88_RS13465 (LXM88_13430) 1846457..1847362 - 906 WP_262542797.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LXM88_RS13470 (LXM88_13435) 1847331..1848404 - 1074 WP_262542798.1 type IV toxin-antitoxin system AbiEi family antitoxin -
LXM88_RS13475 (LXM88_13440) 1848747..1849910 + 1164 WP_262531662.1 M20 aminoacylase family protein -
LXM88_RS13480 (LXM88_13445) 1850089..1850628 + 540 WP_262531663.1 outer membrane protein assembly factor BamE -
LXM88_RS13485 (LXM88_13450) 1850750..1850995 + 246 WP_262531664.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LXM88_RS13490 (LXM88_13455) 1850985..1851284 + 300 WP_262531665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXM88_RS13495 (LXM88_13460) 1851375..1852679 - 1305 WP_262531666.1 cobyrinate a,c-diamide synthase -
LXM88_RS13500 (LXM88_13465) 1852682..1853284 - 603 WP_034184156.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
LXM88_RS13505 (LXM88_13470) 1853319..1853696 - 378 WP_262531667.1 cobalamin biosynthesis protein -
LXM88_RS13510 (LXM88_13475) 1853693..1854502 - 810 WP_262531668.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-94)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11598.27 Da        Isoelectric Point: 7.1280

>T230888 WP_262531665.1 NZ_CP090483:1850985-1851284 [Burkholderia sp. S-53]
MAVKGRQLQLTPLAELDLADIWRYTVEHWSLEQADHYHRDLIGTMEALAHGKKAGRTCIVRDGYLRYAIGSHVVFYRETD
NTIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T230888 NZ_CP125640:1410657-1410785 [Rhizobium sp. BT03]
ATGACAACGTATAGCGACAATACGATCTGGCAGGATGTCTATCACGCCGATACGCCGGCCGGGAAGGCTTATGTCAAAGT
CACGCTGAGGGAAGACGGTGCACCCGTCATCCAGTTCACGGAGTTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8664.63 Da        Isoelectric Point: 6.7231

>AT230888 WP_262531664.1 NZ_CP090483:1850750-1850995 [Burkholderia sp. S-53]
MSRNTSVSLGDHFAEFVDAQVQSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEASGAPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT230888 NZ_CP125640:1410827-1411195 [Rhizobium sp. BT03]
ATGACACCATTCTTCAACGAAACTCACCACGTTACGTTTCGCAATCTGAAAGCTGATGTCGAAGGTTTATCCGGTTTTCG
CTGCGGCGCATGCGGCGAGATCGAGTATGACCAGATCAGTGCCGAGCGTTATGCCCGGGCTAGTGATGCGCTCATCCTGC
AGGATCGGCGAGCCGTCGGCGAGGATCTGCGTCGAATTCGCAAGAAACTGCGCCTCAATCAGACTGAAGCCTCTGCACTG
ACCGGTGGGGGGCACAATGCCTTCTCTCGCTATGAGACGGGAAAAGTCAGTCCGTCACCTGCCGTCGTCAATCTTTTCCG
TCTGCTCGAGCGGCATCCCGACGACATAGAGGAATTGCGACGCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References