Detailed information of TA system TA230887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1845732..1846408
• Replicon: chromosome
• Accession: NZ_CP090483
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A0A0J5X1U9
• Locus tag: LXM88_RS13460
• Protein ID: WP_027787436.1
• Coordinates: 1845992..1846408 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: LXM88_RS13455
• Protein ID: WP_262542796.1
• Coordinates: 1845732..1845995 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS13440 (LXM88_13405)	1841281..1843542	+	2262	WP_262542791.1	TonB-dependent siderophore receptor	-
LXM88_RS13445 (LXM88_13410)	1843626..1844465	+	840	WP_262542792.1	formyltransferase family protein	-
LXM88_RS13450 (LXM88_13415)	1844465..1845481	+	1017	WP_262542794.1	GNAT family N-acetyltransferase	-
LXM88_RS13455 (LXM88_13420)	1845732..1845995	+	264	WP_262542796.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LXM88_RS13460 (LXM88_13425)	1845992..1846408	+	417	WP_027787436.1	PIN domain-containing protein	Toxin
LXM88_RS13465 (LXM88_13430)	1846457..1847362	-	906	WP_262542797.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
LXM88_RS13470 (LXM88_13435)	1847331..1848404	-	1074	WP_262542798.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
LXM88_RS13475 (LXM88_13440)	1848747..1849910	+	1164	WP_262531662.1	M20 aminoacylase family protein	-
LXM88_RS13480 (LXM88_13445)	1850089..1850628	+	540	WP_262531663.1	outer membrane protein assembly factor BamE	-
LXM88_RS13485 (LXM88_13450)	1850750..1850995	+	246	WP_262531664.1	type II toxin-antitoxin system ParD family antitoxin	-
LXM88_RS13490 (LXM88_13455)	1850985..1851284	+	300	WP_262531665.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14536.66 Da
• Isoelectric Point: 7.8895

>T230887 WP_027787436.1 NZ_CP090483:1845992-1846408 [Burkholderia sp. S-53]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Nucleotide

• Length: 417 bp

>T230887 NZ_CP125639:353976-354266 [Rhizobium leguminosarum]
ATGACAGGCATCATATTTTCTCCTGCTGCGCAAACCGATATTGACAAGATTTGGGATTACACGGCGACGAGTTGGAATGT
CGATCAGGCAGAGCGTTACATCCAGGACATAAGAGACGCCTGCCACGAACTGGCGGAGGGAAGACGGATGAGCCGCCCCT
CGGATATTCGGAAAGGGTACAGAAAGGTCTCTGTTGGCTCTCATTTTCTGTATTTCAAAAGCAATGATGCGGGCCAGATC
ATCGTCGTGCGCATCCTTCATCAAAGAATGGACGTAGCCAAGCACCTGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9789.04 Da
• Isoelectric Point: 4.5230

>AT230887 WP_262542796.1 NZ_CP090483:1845732-1845995 [Burkholderia sp. S-53]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADADFLAERPAIIESGRFDLSGDAG
EPTESGR

Nucleotide

• Length: 264 bp

>AT230887 NZ_CP125639:353731-353979 [Rhizobium leguminosarum]
ATGGCCAGAAATACGTCCATATCGCTCGGCGAGCATTTCACCAGCTTCATCGATACGCAAGTTCAGGCTGGCCGCTATGG
TTCAGCCACTGACGTTGTTCGGGCCGGCCTTCGCCTACTTGAAGAACACGAAGCCAAAGTGAAGGCATTACAGGACGCCT
TGATAGAAGGCGAGGAATCCGGCCCTGCCACGCCCTTTGATTTCGATGCGTTCAACGCTCGCAAACGTGCGGTGTTCGAG
GCGAAATGA

Structures

Toxin

• AlphaFold DB: A0A0J5X1U9