Detailed information of TA system TA230886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 186284..186930
• Replicon: chromosome
• Accession: NZ_CP090483
• Organism: Burkholderia sp. S-53

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LXM88_RS05860
• Protein ID: WP_262539442.1
• Coordinates: 186520..186930 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A1K1T0N4
• Locus tag: LXM88_RS05855
• Protein ID: WP_072445316.1
• Coordinates: 186284..186520 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXM88_RS05835 (LXM88_05815)	182190..183284	-	1095	WP_262539435.1	ADP-heptose--LPS heptosyltransferase	-
LXM88_RS05840 (LXM88_05820)	183281..184984	-	1704	WP_262539436.1	thiamine pyrophosphate-binding protein	-
LXM88_RS05845 (LXM88_05825)	185291..185752	+	462	WP_262539438.1	hypothetical protein	-
LXM88_RS05850 (LXM88_05830)	185749..186033	+	285	WP_262539439.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LXM88_RS05855 (LXM88_05835)	186284..186520	+	237	WP_072445316.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LXM88_RS05860 (LXM88_05840)	186520..186930	+	411	WP_262539442.1	type II toxin-antitoxin system VapC family toxin	Toxin
LXM88_RS05865 (LXM88_05845)	186989..188377	-	1389	WP_262539443.1	L-serine ammonia-lyase	-
LXM88_RS05870 (LXM88_05850)	188408..189511	-	1104	WP_262542799.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15325.45 Da
• Isoelectric Point: 4.9203

>T230886 WP_262539442.1 NZ_CP090483:186520-186930 [Burkholderia sp. S-53]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSATTYAELEYGVAACANPDRERRNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLNDSCP

Nucleotide

• Length: 411 bp

>T230886 NZ_CP125638:195643-196047 [Rhizobium leguminosarum]
GTGAGCAGGCCTTATATGCTGGACACCAATATCGTCTCGGAGCTTGCTCGAAACCCGATGGGCACAATCACCCGACGCAT
CGCCGAGGTTGGGCCCGATGCAATTTGCGTCAGCATTATCACGGCGTCGGAGTTGCGCTACGGGTGCGCCAAGAAGGGAT
CACCGAAACTTCTAGCACAGATCGAAGCCATCCTTGGCAGCATACCGGTGCTTGCGCTGGATCTGCCCGCCGATGCTGAA
TACGGTGGCATCCGGGCTGAACTGGAGGCTGCTGGCAAGCCTATCGGTCCAAATGACTTATTCATCGCCGCCCACGCCTC
TGCCCTCGGAGCAGTTCTGGTGACGGCGAACATGGGCGAGTTCATGCGTATCCGCGCTTTGCAGGTCGAAAACTGGTTGA
TTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9059.17 Da
• Isoelectric Point: 5.8835

>AT230886 WP_072445316.1 NZ_CP090483:186284-186520 [Burkholderia sp. S-53]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPTRRPLTRVLEKFAKFGPDFMSEGRGDQEQAEREGL

Nucleotide

• Length: 237 bp

>AT230886 NZ_CP125638:195377-195646 [Rhizobium leguminosarum]
GTGGTCAATTCCCGACATCAAGAGCCTATTCCCCAGCGGGAGGCCAAGCTTTTCAGAAACAACAAGAGTCAGGCTGTACG
AATCCCGGCTGACTTTGAGCTACCCGGTGACCGAGTGATGATCCACCGCGACGGCGATCGGCTCATTATAGAGCCTGTGC
ACCGGAAGAACCTCCTGGAAGTTCTGGCTGGTTTGGAGCCGCTTGGTCCTGAAGATCAGTTTCCCGATGTCGACGATACC
CTGCTTCCTGTGAAGGAAATCGACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1K1T0N4