Detailed information of TA system TA230883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2029882..2030350
• Replicon: chromosome
• Accession: NZ_CP090475
• Organism: Staphylococcus haemolyticus strain BC5211

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q4L4Q4
• Locus tag: LUR16_RS09840
• Protein ID: WP_011276326.1
• Coordinates: 2030162..2030350 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: Q4L4Q5
• Locus tag: LUR16_RS09835
• Protein ID: WP_011276325.1
• Coordinates: 2029882..2030139 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUR16_RS09800	2025058..2025783	-	726	WP_037558439.1	type I 3-dehydroquinate dehydratase	-
LUR16_RS09805	2025946..2026368	+	423	WP_016931015.1	organic hydroperoxide resistance protein	-
LUR16_RS09810	2026631..2027122	+	492	WP_011276321.1	GNAT family N-acetyltransferase	-
LUR16_RS09815	2027254..2027871	+	618	WP_011276322.1	LysE/ArgO family amino acid transporter	-
LUR16_RS09820	2028058..2028666	-	609	WP_011276323.1	histidine phosphatase family protein	-
LUR16_RS09825	2028894..2029136	+	243	WP_011276324.1	hypothetical protein	-
LUR16_RS09830	2029128..2029331	-	204	WP_033079647.1	sterile alpha motif-like domain-containing protein	-
LUR16_RS09835	2029882..2030139	+	258	WP_011276325.1	hypothetical protein	Antitoxin
LUR16_RS09840	2030162..2030350	+	189	WP_011276326.1	hypothetical protein	Toxin
LUR16_RS09845	2030468..2031049	+	582	WP_033079646.1	lipoprotein N-acylation protein LnsA	-
LUR16_RS09850	2031097..2031333	-	237	WP_016931008.1	hypothetical protein	-
LUR16_RS09855	2031503..2032249	+	747	WP_033079645.1	membrane lipoprotein lipid attachment site-containing protein	-
LUR16_RS09860	2032318..2032926	-	609	WP_033079644.1	GNAT family N-acetyltransferase	-
LUR16_RS09865	2033063..2033809	+	747	WP_033079643.1	poly-gamma-glutamate hydrolase family protein	-
LUR16_RS09870	2033885..2034172	+	288	WP_033079642.1	hypothetical protein	-
LUR16_RS09875	2034416..2034640	+	225	WP_033079641.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7110.80 Da
• Isoelectric Point: 9.6269

>T230883 WP_011276326.1 NZ_CP090475:2030162-2030350 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Nucleotide

• Length: 189 bp

>T230883 NZ_CP125620:3813607-3814017 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9914.97 Da
• Isoelectric Point: 4.0625

>AT230883 WP_011276325.1 NZ_CP090475:2029882-2030139 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Nucleotide

• Length: 258 bp

>AT230883 NZ_CP125620:3813332-3813610 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: A0A2A1KAB5

Antitoxin

• AlphaFold DB: A0A2A1KAX9