Detailed information of TA system TA230882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1098667..1099438
• Replicon: chromosome
• Accession: NZ_CP090475
• Organism: Staphylococcus haemolyticus strain BC5211

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: LUR16_RS05500
• Protein ID: WP_011275410.1
• Coordinates: 1099289..1099438 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: LUR16_RS05495
• Protein ID: WP_011275409.1
• Coordinates: 1098667..1099266 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUR16_RS05475	1094550..1096004	+	1455	WP_011275405.1	ABC transporter substrate-binding protein/permease	-
LUR16_RS05480	1095997..1096719	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
LUR16_RS05485	1096897..1098024	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
LUR16_RS05490	1098025..1098495	+	471	WP_011275408.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LUR16_RS05495	1098667..1099266	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
LUR16_RS05500	1099289..1099438	+	150	WP_011275410.1	SAS053 family protein	Toxin
LUR16_RS05505	1099649..1100044	+	396	WP_011275411.1	hypothetical protein	-
LUR16_RS05510	1100251..1101636	+	1386	WP_011275412.1	class II fumarate hydratase	-
LUR16_RS05515	1101702..1102526	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
LUR16_RS05520	1102714..1103823	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL	896996..1341534	444538

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T230882 WP_011275410.1 NZ_CP090475:1099289-1099438 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T230882 NZ_CP125620:c3786578-3786186 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT230882 WP_011275409.1 NZ_CP090475:1098667-1099266 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT230882 NZ_CP125620:c3786853-3786578 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2