230881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 955100..955632 Replicon chromosome
Accession NZ_CP090475
Organism Staphylococcus haemolyticus strain BC5211

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag LUR16_RS04660 Protein ID WP_011275272.1
Coordinates 955267..955632 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag LUR16_RS04655 Protein ID WP_011275271.1
Coordinates 955100..955270 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUR16_RS04630 950886..951365 + 480 WP_011275266.1 PH domain-containing protein -
LUR16_RS04635 951358..952881 + 1524 WP_016931363.1 PH domain-containing protein -
LUR16_RS04640 952874..953401 + 528 WP_016931364.1 PH domain-containing protein -
LUR16_RS04645 953411..953770 + 360 WP_011275269.1 holo-ACP synthase -
LUR16_RS04650 953866..955014 + 1149 WP_016931365.1 alanine racemase -
LUR16_RS04655 955100..955270 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LUR16_RS04660 955267..955632 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LUR16_RS04665 955940..956941 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
LUR16_RS04670 957040..957366 + 327 WP_011275274.1 anti-sigma factor antagonist -
LUR16_RS04675 957395..957847 + 453 WP_046309853.1 anti-sigma B factor RsbW -
LUR16_RS04680 957822..958592 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 896996..1341534 444538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T230881 WP_011275272.1 NZ_CP090475:955267-955632 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T230881 NZ_CP125620:3757988-3758245 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT230881 WP_011275271.1 NZ_CP090475:955100-955270 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT230881 NZ_CP125620:3757716-3757991 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References