Detailed information of TA system TA230880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 942175..942686
• Replicon: chromosome
• Accession: NZ_CP090475
• Organism: Staphylococcus haemolyticus strain BC5211

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: LUR16_RS04595
• Protein ID: WP_011275259.1
• Coordinates: 942480..942686 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: LUR16_RS04590
• Protein ID: WP_011275258.1
• Coordinates: 942175..942468 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUR16_RS04570	937328..938203	+	876	WP_011275255.1	membrane protein insertase YidC	-
LUR16_RS04575	938398..939714	+	1317	WP_104948180.1	ISL3 family transposase	-
LUR16_RS04580	939763..940404	-	642	WP_016931420.1	HD domain-containing protein	-
LUR16_RS04585	940504..941988	-	1485	WP_016931421.1	cardiolipin synthase	-
LUR16_RS04590	942175..942468	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
LUR16_RS04595	942480..942686	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
LUR16_RS04600	942794..942931	+	138	WP_011275260.1	Lmo0850 family protein	-
LUR16_RS04605	942956..944624	-	1669	Protein_910	IS1182 family transposase	-
LUR16_RS04610	944880..946079	-	1200	WP_048668183.1	FtsW/RodA/SpoVE family cell cycle protein	-
LUR16_RS04615	946497..947567	+	1071	WP_048668181.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL	896996..1341534	444538
	-	inside	IScluster/Tn	-	-	938398..944624	6226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T230880 WP_011275259.1 NZ_CP090475:942480-942686 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T230880 NZ_CP090475:942480-942686 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT230880 WP_011275258.1 NZ_CP090475:942175-942468 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT230880 NZ_CP090475:942175-942468 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8