Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 27541..28184 Replicon plasmid p3
Accession NZ_CP090471
Organism Klebsiella pneumoniae strain kp7450

Toxin (Protein)


Gene name vagD Uniprot ID A0A7D6UII7
Locus tag LZ687_RS27395 Protein ID WP_032425563.1
Coordinates 27541..27957 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID R4IT22
Locus tag LZ687_RS27400 Protein ID WP_016338373.1
Coordinates 27954..28184 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ687_RS27375 (LZ687_27375) 22589..24697 - 2109 WP_016338368.1 peptidase domain-containing ABC transporter -
LZ687_RS27380 (LZ687_27380) 24687..25964 - 1278 WP_016338369.1 HlyD family secretion protein -
LZ687_RS27385 (LZ687_27385) 26623..27159 + 537 WP_223825639.1 hypothetical protein -
LZ687_RS27390 (LZ687_27390) 27177..27500 + 324 WP_085842301.1 hypothetical protein -
LZ687_RS27395 (LZ687_27395) 27541..27957 - 417 WP_032425563.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ687_RS27400 (LZ687_27400) 27954..28184 - 231 WP_016338373.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZ687_RS27405 (LZ687_27405) 28402..29316 - 915 WP_126834912.1 Abi family protein -
LZ687_RS27410 (LZ687_27410) 29609..30562 - 954 WP_109549184.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LZ687_RS27415 (LZ687_27415) 30670..30933 + 264 Protein_41 hypothetical protein -
LZ687_RS27420 (LZ687_27420) 31103..31321 + 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA -
LZ687_RS27425 (LZ687_27425) 31323..31628 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB -
LZ687_RS27430 (LZ687_27430) 31797..32192 + 396 WP_017899885.1 hypothetical protein -
LZ687_RS27435 (LZ687_27435) 32219..32533 + 315 WP_053389906.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / qnrB1 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 - 1..135574 135574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.56 Da        Isoelectric Point: 8.5403

>T230878 WP_032425563.1 NZ_CP090471:c27957-27541 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

>T230878 NZ_CP125620:3166264-3166707 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8751.77 Da        Isoelectric Point: 4.3533

>AT230878 WP_016338373.1 NZ_CP090471:c28184-27954 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWSSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT230878 NZ_CP125620:3166020-3166277 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6UII7

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LN61

References