Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4792814..4793330 Replicon chromosome
Accession NZ_CP090468
Organism Klebsiella pneumoniae strain kp7450

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LZ687_RS23025 Protein ID WP_004178374.1
Coordinates 4792814..4793098 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LZ687_RS23030 Protein ID WP_002886901.1
Coordinates 4793088..4793330 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ687_RS23000 (4788298) 4788298..4788561 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
LZ687_RS23005 (4788691) 4788691..4788864 + 174 WP_032408826.1 hypothetical protein -
LZ687_RS23010 (4788867) 4788867..4789610 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LZ687_RS23015 (4789967) 4789967..4792105 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LZ687_RS23020 (4792346) 4792346..4792810 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LZ687_RS23025 (4792814) 4792814..4793098 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ687_RS23030 (4793088) 4793088..4793330 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZ687_RS23035 (4793408) 4793408..4795318 - 1911 WP_004178373.1 PRD domain-containing protein -
LZ687_RS23040 (4795341) 4795341..4796495 - 1155 WP_004178372.1 lactonase family protein -
LZ687_RS23045 (4796562) 4796562..4797302 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T230873 WP_004178374.1 NZ_CP090468:c4793098-4792814 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T230873 NZ_CP125620:c3054865-3054470 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT230873 WP_002886901.1 NZ_CP090468:c4793330-4793088 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230873 NZ_CP125620:c3054444-3054178 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References