Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 42397..43136 | Replicon | plasmid pKP187 |
| Accession | NC_011282 | ||
| Organism | Klebsiella pneumoniae 342 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | KPK_RS26725 | Protein ID | WP_012540220.1 |
| Coordinates | 42651..43136 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A5E1AWX8 |
| Locus tag | KPK_RS26720 | Protein ID | WP_012540086.1 |
| Coordinates | 42397..42663 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPK_RS26690 | 37628..38164 | - | 537 | WP_012540238.1 | GNAT family N-acetyltransferase | - |
| KPK_RS26695 | 38289..40040 | - | 1752 | WP_012540216.1 | arsenical pump-driving ATPase | - |
| KPK_RS26700 | 40067..40429 | - | 363 | WP_012540155.1 | arsenic metallochaperone ArsD family protein | - |
| KPK_RS26705 | 40505..41050 | - | 546 | WP_012540227.1 | sigma-70 family RNA polymerase sigma factor | - |
| KPK_RS26710 | 41059..41772 | - | 714 | WP_012540184.1 | arsenical resistance protein ArsH | - |
| KPK_RS26715 | 41774..42097 | - | 324 | WP_012540250.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KPK_RS26720 | 42397..42663 | + | 267 | WP_012540086.1 | DUF1778 domain-containing protein | Antitoxin |
| KPK_RS26725 | 42651..43136 | + | 486 | WP_012540220.1 | GNAT family N-acetyltransferase | Toxin |
| KPK_RS31415 | 43476..43580 | + | 105 | Protein_45 | Hok/Gef family protein | - |
| KPK_RS26730 | 43841..44218 | - | 378 | WP_012540069.1 | hypothetical protein | - |
| KPK_RS26740 | 44783..45289 | + | 507 | Protein_47 | hypothetical protein | - |
| KPK_RS26745 | 45400..45903 | - | 504 | WP_012540230.1 | hypothetical protein | - |
| KPK_RS30315 | 46196..46891 | + | 696 | WP_077251732.1 | integrase arm-type DNA-binding domain-containing protein | - |
| KPK_RS31420 | 46949..47128 | + | 180 | WP_012540246.1 | hypothetical protein | - |
| KPK_RS31425 | 47083..47289 | + | 207 | Protein_51 | hypothetical protein | - |
| KPK_RS30320 | 47286..47630 | + | 345 | WP_012540217.1 | hypothetical protein | - |
| KPK_RS26765 | 47515..47997 | + | 483 | WP_041165485.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..187922 | 187922 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17836.65 Da Isoelectric Point: 9.7733
>T23087 WP_012540220.1 NC_011282:42651-43136 [Klebsiella variicola]
VGRVTVPEPLSSFYQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q
VGRVTVPEPLSSFYQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q
Download Length: 486 bp
>T23087 NC_011282:42651-43136 [Klebsiella variicola]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTTATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTTATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10076.47 Da Isoelectric Point: 4.3721
>AT23087 WP_012540086.1 NC_011282:42397-42663 [Klebsiella variicola]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
Download Length: 267 bp
>AT23087 NC_011282:42397-42663 [Klebsiella variicola]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCCAAGGAATCACAGCGGGCGCTCATTGACGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAATGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCAGATGTTCAACTTAATCTTAGAGCCAAGGAATCACAGCGGGCGCTCATTGACGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAATGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|