Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916831..4917347 Replicon chromosome
Accession NZ_CP090462
Organism Klebsiella pneumoniae strain kp5152

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LZ688_RS24355 Protein ID WP_002886902.1
Coordinates 4916831..4917115 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LZ688_RS24360 Protein ID WP_002886901.1
Coordinates 4917105..4917347 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ688_RS24330 (LZ688_24330) 4912315..4912578 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LZ688_RS24335 (LZ688_24335) 4912708..4912881 + 174 WP_002886906.1 hypothetical protein -
LZ688_RS24340 (LZ688_24340) 4912884..4913627 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LZ688_RS24345 (LZ688_24345) 4913984..4916122 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LZ688_RS24350 (LZ688_24350) 4916363..4916827 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LZ688_RS24355 (LZ688_24355) 4916831..4917115 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ688_RS24360 (LZ688_24360) 4917105..4917347 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZ688_RS24365 (LZ688_24365) 4917425..4919335 - 1911 WP_004152270.1 PRD domain-containing protein -
LZ688_RS24370 (LZ688_24370) 4919358..4920512 - 1155 WP_002886900.1 lactonase family protein -
LZ688_RS24375 (LZ688_24375) 4920578..4921318 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T230843 WP_002886902.1 NZ_CP090462:c4917115-4916831 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T230843 NZ_CP125620:1016690-1017124 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT230843 WP_002886901.1 NZ_CP090462:c4917347-4917105 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230843 NZ_CP125620:1016505-1016684 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References