Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4198341..4198960 Replicon chromosome
Accession NZ_CP090462
Organism Klebsiella pneumoniae strain kp5152

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LZ688_RS20910 Protein ID WP_002892050.1
Coordinates 4198742..4198960 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LZ688_RS20905 Protein ID WP_002892066.1
Coordinates 4198341..4198715 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ688_RS20895 (LZ688_20895) 4193493..4194686 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LZ688_RS20900 (LZ688_20900) 4194709..4197855 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LZ688_RS20905 (LZ688_20905) 4198341..4198715 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LZ688_RS20910 (LZ688_20910) 4198742..4198960 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LZ688_RS20915 (LZ688_20915) 4199119..4199685 + 567 WP_002892030.1 maltose O-acetyltransferase -
LZ688_RS20920 (LZ688_20920) 4199657..4199797 - 141 WP_004147370.1 hypothetical protein -
LZ688_RS20925 (LZ688_20925) 4199818..4200288 + 471 WP_002892026.1 YlaC family protein -
LZ688_RS20930 (LZ688_20930) 4200263..4201714 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LZ688_RS20935 (LZ688_20935) 4201815..4202513 + 699 WP_002892021.1 GNAT family protein -
LZ688_RS20940 (LZ688_20940) 4202510..4202650 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LZ688_RS20945 (LZ688_20945) 4202650..4202913 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230841 WP_002892050.1 NZ_CP090462:4198742-4198960 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230841 NZ_CP125620:c756140-755703 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230841 WP_002892066.1 NZ_CP090462:4198341-4198715 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230841 NZ_CP125620:c756391-756137 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References