Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875385..876039 Replicon chromosome
Accession NZ_CP090462
Organism Klebsiella pneumoniae strain kp5152

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LZ688_RS04405 Protein ID WP_004144731.1
Coordinates 875632..876039 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LZ688_RS04400 Protein ID WP_002916312.1
Coordinates 875385..875651 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ688_RS04375 (LZ688_04375) 870541..871974 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LZ688_RS04380 (LZ688_04380) 872093..872821 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LZ688_RS04385 (LZ688_04385) 872871..873182 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LZ688_RS04390 (LZ688_04390) 873346..874005 + 660 WP_002916317.1 hemolysin III family protein -
LZ688_RS04395 (LZ688_04395) 874156..875139 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LZ688_RS04400 (LZ688_04400) 875385..875651 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LZ688_RS04405 (LZ688_04405) 875632..876039 + 408 WP_004144731.1 protein YgfX Toxin
LZ688_RS04410 (LZ688_04410) 876046..876567 - 522 WP_002916308.1 flavodoxin FldB -
LZ688_RS04415 (LZ688_04415) 876668..877564 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LZ688_RS04420 (LZ688_04420) 877587..878300 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZ688_RS04425 (LZ688_04425) 878306..880039 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T230831 WP_004144731.1 NZ_CP090462:875632-876039 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T230831 NZ_CP125620:677757-678164 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230831 WP_002916312.1 NZ_CP090462:875385-875651 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230831 NZ_CP125620:677545-677760 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References