Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4295075..4295572 Replicon chromosome
Accession NZ_CP090456
Organism Escherichia coli strain B379

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LZ684_RS20695 Protein ID WP_001173343.1
Coordinates 4295075..4295248 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LZ684_RS20700 Protein ID WP_000398619.1
Coordinates 4295276..4295572 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ684_RS20685 (4291745) 4291745..4293202 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
LZ684_RS20690 (4293439) 4293439..4294956 + 1518 WP_001295074.1 lysine--tRNA ligase -
LZ684_RS20695 (4295075) 4295075..4295248 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LZ684_RS20700 (4295276) 4295276..4295572 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LZ684_RS20705 (4295799) 4295799..4296071 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
LZ684_RS20710 (4296083) 4296083..4296313 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
LZ684_RS20715 (4296494) 4296494..4298125 + 1632 WP_001216477.1 sensor histidine kinase -
LZ684_RS20720 (4298122) 4298122..4298841 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T230820 WP_001173343.1 NZ_CP090456:c4295248-4295075 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T230820 NZ_CP125619:c1149613-1149359 [Pseudomonas sp. PMCC200367]
ATGCAAACCATCAACTACACCACCGCACGTGCACATCTGGCCGAAACCATGGATCGGGTCAATGAAGACCGCGCTCCACT
GTTGGTCACTCGCCAGAAAGGCGAACCCGTGGTGATGATGTCTCTGGCGGAGTACAACGCCCTCGAAGAGACAGCCTATC
TACTTCGCTCCCCTGCTAATGCAGAACGCTTGATCAAATCGATCGGCAACCTGCGAGCAGGGAAAACTAAAACCAGGCAA
CTCATCGAAGAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT230820 WP_000398619.1 NZ_CP090456:c4295572-4295276 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT230820 NZ_CP125619:c1149362-1149108 [Pseudomonas sp. PMCC200367]
ATGAATATCGAGTTCACTCCTGAAGGTTGGGAAGACTATCTGTGGTTCCAACAAAACGATAAGGCAGGACTCAAGCGAAT
CAACCTGCTGATCAAATCAATCCAGCGCGAGCCGTTCGATGGACTCGGAAAACCTGAACCGCTCAAATACAACTTGAGCG
GCTTCTGGTCGCGCCGGATTACAGCCGAGCATCGCTTGGTCTATGCAGTCGAGGATGGTGAAATCCGCGTTGTGATGTGT
AGATATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References