Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3518191..3518809 Replicon chromosome
Accession NZ_CP090456
Organism Escherichia coli strain B379

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LZ684_RS16885 Protein ID WP_001291435.1
Coordinates 3518591..3518809 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LZ684_RS16880 Protein ID WP_000344800.1
Coordinates 3518191..3518565 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ684_RS16870 (3513280) 3513280..3514473 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LZ684_RS16875 (3514496) 3514496..3517645 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LZ684_RS16880 (3518191) 3518191..3518565 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LZ684_RS16885 (3518591) 3518591..3518809 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LZ684_RS16890 (3518981) 3518981..3519532 + 552 WP_000102564.1 maltose O-acetyltransferase -
LZ684_RS16895 (3519648) 3519648..3520118 + 471 WP_000136192.1 YlaC family protein -
LZ684_RS16900 (3520282) 3520282..3521832 + 1551 WP_234679171.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LZ684_RS16905 (3521874) 3521874..3522227 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LZ684_RS16915 (3522606) 3522606..3522917 + 312 WP_000409911.1 MGMT family protein -
LZ684_RS16920 (3522948) 3522948..3523520 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230816 WP_001291435.1 NZ_CP090456:3518591-3518809 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T230816 NZ_CP125619:247521-247703 [Pseudomonas sp. PMCC200367]
ATGCGAAGTCGGGAAATGATCAGGATGATCGAGGAGGATGGTTGGTATCTGGTGGCCGTGAAAGGCAGCCATCATCAGTA
CAAGCATCCGTGCAAGCCAGGGAGGGTGACGATAAAGCACCCGGACTCGGATCTTCCAAAAGGAACGATCAACAGCATAT
TGAAACAGGCGGGTCTGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT230816 WP_000344800.1 NZ_CP090456:3518191-3518565 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT230816 NZ_CP125619:247700-248164 [Pseudomonas sp. PMCC200367]
ATGAGCCCCGACACCGGATACGAAAGCCCCGAGCGGGCCACATCACAGGAAGGACTTAGCGAAATGAAATTCCCGGTCGT
TCTGCACAAGGATGCCGACTCAGAATACGGAGTAATTATCCCGGACGTGCCGGGTTGTTTCTCCGCAGGCGGTACTGTGG
CGCAGGCATTTGAAAACGTGAAGGAAGCGCTGTCGTTGCACTACGAAGGCTTGGTGGCCGATGGCGATCCACTGCCGCAG
GTGCATGAGATCGACGCTCATCTTGATAACCCTGATTACGCCGGCGGCGTGTGGGGTGTGGTCGAATTCGATATCACGCC
TTACTTCGGAAAGTCGGTGCGCTTCAATGCCACACTGCCTGAGCAGTTGCTTGAGCGTATTGATCAAACAGTCAGGCGGG
ATCAGCGGTACAGCTCAAGGTCTGGCTTTTTGGCTGCCGCTGCCCTGCGTGAGTTGTCGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References