Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1909013..1909844 Replicon chromosome
Accession NZ_CP090456
Organism Escherichia coli strain B379

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag LZ684_RS09050 Protein ID WP_000854814.1
Coordinates 1909013..1909387 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag LZ684_RS09055 Protein ID WP_001285585.1
Coordinates 1909476..1909844 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ684_RS09010 (1904409) 1904409..1905575 + 1167 WP_001618666.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
LZ684_RS09015 (1905694) 1905694..1906167 + 474 WP_001105412.1 DNA gyrase inhibitor SbmC -
LZ684_RS09020 (1906365) 1906365..1907423 + 1059 WP_001200891.1 FUSC family protein -
LZ684_RS09025 (1907595) 1907595..1907924 + 330 WP_000450409.1 DUF496 family protein -
LZ684_RS09030 (1908025) 1908025..1908159 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
LZ684_RS09035 (1908279) 1908279..1908407 + 129 Protein_1768 transposase domain-containing protein -
LZ684_RS09040 (1908696) 1908696..1908776 - 81 Protein_1769 hypothetical protein -
LZ684_RS09045 (1908822) 1908822..1909016 - 195 WP_000988600.1 DUF5983 family protein -
LZ684_RS09050 (1909013) 1909013..1909387 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LZ684_RS09055 (1909476) 1909476..1909844 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LZ684_RS09060 (1909918) 1909918..1910139 - 222 WP_000692323.1 DUF987 domain-containing protein -
LZ684_RS09065 (1910202) 1910202..1910678 - 477 WP_001186773.1 RadC family protein -
LZ684_RS09070 (1910694) 1910694..1910819 - 126 Protein_1775 antirestriction protein -
LZ684_RS09075 (1910987) 1910987..1912528 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
LZ684_RS09080 (1912543) 1912543..1913289 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
LZ684_RS09085 (1913374) 1913374..1913760 - 387 Protein_1778 antirestriction protein -
LZ684_RS09090 (1913842) 1913842..1914663 - 822 WP_001234530.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T230806 WP_000854814.1 NZ_CP090456:c1909387-1909013 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T230806 NZ_CP125618:258899-259081 [Pseudomonas sp. PMCC200344]
ATGCGAAGTCGGGAAATGATCAGGATGATCGAGGAGGATGGTTGGTATCTGGTGGCCGTGAAAGGCAGCCATCATCAGTA
CAAGCATCCGTGCAAGCCAGGGAGGGTGACGATAAAGCACCCGGACTCGGATCTTCCAAAAGGAACGATCAACAGCATAT
TGAAACAGGCGGGTCTGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT230806 WP_001285585.1 NZ_CP090456:c1909844-1909476 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT230806 NZ_CP125618:259078-259542 [Pseudomonas sp. PMCC200344]
ATGAGCCCCGACACCGGATACGAAAGCCCCGAGCGGGCCACATCACAGGAAGGAATTAGCGAAATGAAATTCCCGGTCGT
TCTGCACAAGGATGCCGACTCAGAATACGGAGTAATTATCCCGGACGTGCCGGGTTGTTTCTCCGCAGGCGGTACTGTGG
CGCAGGCATTTGAAAACGTGAAGGAAGCGCTGTCGTTGCACTACGAAGGCTTGGTGGCCGATGGCGATCCACTGCCGCAG
GTGCATGAGATCGACGCTCATCTTGATAACCCTGATTACGCCGGCGGCGTGTGGGGTGTGGTCGAATTCGATATCACGCC
TTACTTCGGAAAGTCGGTGCGCTTCAATGCCACACTGCCTGAGCAGTTGCTTGAGCGTATTGATCAAACAGTCAGGCGGG
ATCAGCGGTACAGCTCAAGGTCTGGCTTTTTGGCTGCCGCTGCCCTGCGTGAGTTGTCGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References