Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1234975..1235642 Replicon chromosome
Accession NZ_CP090456
Organism Escherichia coli strain B379

Toxin (Protein)


Gene name ypjF Uniprot ID A0A156PNF2
Locus tag LZ684_RS05950 Protein ID WP_001618791.1
Coordinates 1234975..1235304 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A156PNH9
Locus tag LZ684_RS05955 Protein ID WP_001618790.1
Coordinates 1235325..1235642 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ684_RS05945 (1230030) 1230030..1234610 + 4581 WP_001403181.1 adhesin-like autotransporter YpjA/EhaD -
LZ684_RS05950 (1234975) 1234975..1235304 - 330 WP_001618791.1 TA system toxin CbtA family protein Toxin
LZ684_RS05955 (1235325) 1235325..1235642 - 318 WP_001618790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LZ684_RS05960 (1235661) 1235661..1235882 - 222 WP_001618789.1 DUF987 domain-containing protein -
LZ684_RS05965 (1235891) 1235891..1236367 - 477 WP_001618788.1 RadC family protein -
LZ684_RS05970 (1236383) 1236383..1236841 - 459 WP_000211838.1 antirestriction protein -
LZ684_RS05975 (1236939) 1236939..1237178 - 240 WP_001115184.1 DUF905 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1209614..1267210 57596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12509.43 Da        Isoelectric Point: 7.2767

>T230804 WP_001618791.1 NZ_CP090456:c1235304-1234975 [Escherichia coli]
MNTLPATTQRAAKPCLSPVAVWKMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADTVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK

Download         Length: 330 bp

>T230804 NZ_CP125367:c5961629-5961351 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTTGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11905.54 Da        Isoelectric Point: 7.3234

>AT230804 WP_001618790.1 NZ_CP090456:c1235642-1235325 [Escherichia coli]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT230804 NZ_CP125367:c5961339-5961034 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A156PNF2

Antitoxin

Source ID Structure
AlphaFold DB A0A156PNH9

References