Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1180726..1181567 Replicon chromosome
Accession NZ_CP090456
Organism Escherichia coli strain B379

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag LZ684_RS05715 Protein ID WP_000854822.1
Coordinates 1180726..1181109 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag LZ684_RS05720 Protein ID WP_053271974.1
Coordinates 1181199..1181567 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ684_RS05690 (1176110) 1176110..1178362 - 2253 Protein_1112 alpha-amylase family glycosyl hydrolase -
LZ684_RS05700 (1179096) 1179096..1179941 - 846 WP_001280435.1 DUF4942 domain-containing protein -
LZ684_RS05705 (1180038) 1180038..1180235 - 198 WP_000839263.1 DUF957 domain-containing protein -
LZ684_RS05710 (1180247) 1180247..1180735 - 489 WP_001177592.1 DUF5983 family protein -
LZ684_RS05715 (1180726) 1180726..1181109 - 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LZ684_RS05720 (1181199) 1181199..1181567 - 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LZ684_RS05725 (1181647) 1181647..1181868 - 222 WP_000692312.1 DUF987 domain-containing protein -
LZ684_RS05730 (1181937) 1181937..1182413 - 477 WP_001186747.1 RadC family protein -
LZ684_RS05735 (1182428) 1182428..1182913 - 486 WP_000214317.1 antirestriction protein -
LZ684_RS05740 (1183004) 1183004..1183822 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T230803 WP_000854822.1 NZ_CP090456:c1181109-1180726 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T230803 NZ_CP125367:c5745978-5745679 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT230803 WP_053271974.1 NZ_CP090456:c1181567-1181199 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT230803 NZ_CP125367:c5745682-5745392 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References