Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 5613543..5615233 | Replicon | chromosome |
| Accession | NZ_CP090445 | ||
| Organism | Comamonas testosteroni strain X13 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LZ683_RS26295 | Protein ID | WP_182284981.1 |
| Coordinates | 5614355..5615233 (-) | Length | 293 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | LZ683_RS26290 | Protein ID | WP_182284980.1 |
| Coordinates | 5613543..5614349 (-) | Length | 269 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ683_RS26270 (LZ683_26235) | 5609540..5610316 | - | 777 | WP_182284976.1 | SDR family oxidoreductase | - |
| LZ683_RS26275 (LZ683_26240) | 5610633..5611391 | - | 759 | WP_275053662.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| LZ683_RS26280 (LZ683_26245) | 5611522..5612508 | - | 987 | WP_182284978.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| LZ683_RS26285 (LZ683_26250) | 5612700..5613500 | - | 801 | WP_275053663.1 | aspartate dehydrogenase | - |
| LZ683_RS26290 (LZ683_26255) | 5613543..5614349 | - | 807 | WP_182284980.1 | IclR family transcriptional regulator | Antitoxin |
| LZ683_RS26295 (LZ683_26260) | 5614355..5615233 | - | 879 | WP_182284981.1 | alpha/beta hydrolase | Toxin |
| LZ683_RS26300 (LZ683_26265) | 5615242..5615775 | - | 534 | WP_003072476.1 | cupin domain-containing protein | - |
| LZ683_RS26305 (LZ683_26270) | 5616036..5617712 | - | 1677 | WP_182284982.1 | long-chain-fatty-acid--CoA ligase | - |
| LZ683_RS26310 (LZ683_26275) | 5618102..5618248 | + | 147 | WP_165963129.1 | hypothetical protein | - |
| LZ683_RS26315 (LZ683_26280) | 5618281..5618562 | - | 282 | WP_275053664.1 | DUF2274 domain-containing protein | - |
| LZ683_RS26320 (LZ683_26285) | 5618559..5619818 | - | 1260 | WP_275053665.1 | TrbI/VirB10 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 293 a.a. Molecular weight: 30664.19 Da Isoelectric Point: 6.3787
>T230760 WP_182284981.1 NZ_CP090445:c5615233-5614355 [Comamonas testosteroni]
MHEDLLSLKLQLLQTGFPERLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGATAKAEQQAKVRE
GRLASLAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
MHEDLLSLKLQLLQTGFPERLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGATAKAEQQAKVRE
GRLASLAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
Download Length: 879 bp
>T230760 NZ_CP125351:c3889035-3888628 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCCCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCCCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 269 a.a. Molecular weight: 29313.27 Da Isoelectric Point: 5.1709
>AT230760 WP_182284980.1 NZ_CP090445:c5614349-5613543 [Comamonas testosteroni]
MSETPEISTNEQDRYTVPALDRGLRLLACFGPEQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
MSETPEISTNEQDRYTVPALDRGLRLLACFGPEQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
Download Length: 807 bp
>AT230760 NZ_CP125351:c3889282-3889016 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|