Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5613543..5615233 Replicon chromosome
Accession NZ_CP090445
Organism Comamonas testosteroni strain X13

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LZ683_RS26295 Protein ID WP_182284981.1
Coordinates 5614355..5615233 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LZ683_RS26290 Protein ID WP_182284980.1
Coordinates 5613543..5614349 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ683_RS26270 (LZ683_26235) 5609540..5610316 - 777 WP_182284976.1 SDR family oxidoreductase -
LZ683_RS26275 (LZ683_26240) 5610633..5611391 - 759 WP_275053662.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
LZ683_RS26280 (LZ683_26245) 5611522..5612508 - 987 WP_182284978.1 tripartite tricarboxylate transporter substrate binding protein -
LZ683_RS26285 (LZ683_26250) 5612700..5613500 - 801 WP_275053663.1 aspartate dehydrogenase -
LZ683_RS26290 (LZ683_26255) 5613543..5614349 - 807 WP_182284980.1 IclR family transcriptional regulator Antitoxin
LZ683_RS26295 (LZ683_26260) 5614355..5615233 - 879 WP_182284981.1 alpha/beta hydrolase Toxin
LZ683_RS26300 (LZ683_26265) 5615242..5615775 - 534 WP_003072476.1 cupin domain-containing protein -
LZ683_RS26305 (LZ683_26270) 5616036..5617712 - 1677 WP_182284982.1 long-chain-fatty-acid--CoA ligase -
LZ683_RS26310 (LZ683_26275) 5618102..5618248 + 147 WP_165963129.1 hypothetical protein -
LZ683_RS26315 (LZ683_26280) 5618281..5618562 - 282 WP_275053664.1 DUF2274 domain-containing protein -
LZ683_RS26320 (LZ683_26285) 5618559..5619818 - 1260 WP_275053665.1 TrbI/VirB10 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, C-terminal

(137-257)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30664.19 Da        Isoelectric Point: 6.3787

>T230760 WP_182284981.1 NZ_CP090445:c5615233-5614355 [Comamonas testosteroni]
MHEDLLSLKLQLLQTGFPERLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGATAKAEQQAKVRE
GRLASLAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Download         Length: 879 bp

>T230760 NZ_CP125351:c3889035-3888628 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCCCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29313.27 Da        Isoelectric Point: 5.1709

>AT230760 WP_182284980.1 NZ_CP090445:c5614349-5613543 [Comamonas testosteroni]
MSETPEISTNEQDRYTVPALDRGLRLLACFGPEQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR

Download         Length: 807 bp

>AT230760 NZ_CP125351:c3889282-3889016 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References