Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3319622..3320187 Replicon chromosome
Accession NZ_CP090442
Organism Rhodococcus sp. DMF-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LZP97_RS15020 Protein ID WP_048774004.1
Coordinates 3319622..3319978 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A8D4K486
Locus tag LZP97_RS15025 Protein ID WP_040270291.1
Coordinates 3319975..3320187 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZP97_RS15005 (LZP97_15005) 3314951..3316693 - 1743 WP_059174979.1 hypothetical protein -
LZP97_RS15010 (LZP97_15010) 3317240..3318298 - 1059 WP_048774008.1 beta-mannosidase -
LZP97_RS15015 (LZP97_15015) 3318729..3319547 + 819 WP_234574725.1 hypothetical protein -
LZP97_RS15020 (LZP97_15020) 3319622..3319978 - 357 WP_048774004.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZP97_RS15025 (LZP97_15025) 3319975..3320187 - 213 WP_040270291.1 ribbon-helix-helix protein, CopG family Antitoxin
LZP97_RS15030 (LZP97_15030) 3320396..3320977 + 582 WP_040270289.1 GNAT family N-acetyltransferase -
LZP97_RS15035 (LZP97_15035) 3320985..3322016 - 1032 WP_040270287.1 hypothetical protein -
LZP97_RS15040 (LZP97_15040) 3322130..3323104 - 975 WP_017679963.1 helix-turn-helix domain-containing protein -
LZP97_RS15045 (LZP97_15045) 3323242..3323880 + 639 WP_048774002.1 isochorismatase family protein -
LZP97_RS15050 (LZP97_15050) 3324074..3324478 - 405 WP_048774000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3308488..3320187 11699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12791.63 Da        Isoelectric Point: 10.4269

>T230759 WP_048774004.1 NZ_CP090442:c3319978-3319622 [Rhodococcus sp. DMF-1]
MIRRAQIHWVDPDPVQGSEAAKRRPAVVVSNDRANATAENLGRGVVTVVPLIASTSHVFPFQVLVEPDESGLARASKAQA
EQVRSVSVRRLDAEPVGKLGVRTLAALDEALRLHLDLR

Download         Length: 357 bp

>T230759 NZ_CP125351:c3803954-3803556 [Escherichia fergusonii]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCCAAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTCTAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGATTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACA
AATGACGAAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGTAAGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7680.46 Da        Isoelectric Point: 4.1694

>AT230759 WP_040270291.1 NZ_CP090442:c3320187-3319975 [Rhodococcus sp. DMF-1]
MTVKFTISLPDEDVHVLDEYIRDHGLRGRSAGVRAAVRLLAAAGLERDYATAFAEVDTDDAWDVTTADTE

Download         Length: 213 bp

>AT230759 NZ_CP125351:c3804250-3803957 [Escherichia fergusonii]
ATGCATCGAATTCTTGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATATTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGTCCATAAAGGCGCGTTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References